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Titolo:
EFFECTS OF REPEATED ADMINISTRATION OF 3,4-METHYLENEDIOXYMETHAMPHETAMINE ON 5-HYDROXYTRYPTAMINE NEURONAL-ACTIVITY AND RELEASE IN THE RAT-BRAIN IN-VIVO
Autore:
GARTSIDE SE; MCQUADE R; SHARP T;
Indirizzi:
UNIV OXFORD,RADCLIFFE INFIRM,DEPT CLIN PHARMACOL,WOODSTOCK RD OXFORD OX2 6HE ENGLAND
Titolo Testata:
The Journal of pharmacology and experimental therapeutics
fascicolo: 1, volume: 279, anno: 1996,
pagine: 277 - 283
SICI:
0022-3565(1996)279:1<277:EORAO3>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAN RAPHE NUCLEI; SEROTONERGIC NEURONS; DORSAL RAPHE; NEUROTOXIC AMPHETAMINE; ELECTRICAL-STIMULATION; CHLOROAMPHETAMINE PCA; DOPAMINERGIC-NEURONS; AXON TERMINALS; D-FENFLURAMINE; MDMA ECSTASY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
S.E. Gartside et al., "EFFECTS OF REPEATED ADMINISTRATION OF 3,4-METHYLENEDIOXYMETHAMPHETAMINE ON 5-HYDROXYTRYPTAMINE NEURONAL-ACTIVITY AND RELEASE IN THE RAT-BRAIN IN-VIVO", The Journal of pharmacology and experimental therapeutics, 279(1), 1996, pp. 277-283

Abstract

In experimental animals, administration of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) leads to extensive, but incomplete, loss of 5-hydroxytryptamine (5-HT) innervation in the brain. Here, we report theeffects of MDMA on 5-HT neuronal function measured in the rat in vivousing electrophysiological and microdialysis techniques. Two weeks after administration of an established neurotoxic regimen of MDMA (20 mg/kg s.c., twice daily for 4 days) we found; 1) no change in either thedensity or the firing activity of 5-HT neurons in the dorsal raphe nucleus; 2) no change in basal extracellular 5-HT in either the frontal cortex or the hippocampus, although extracellular 5-hydroxyindoleacetic acid was reduced by about 50% in both regions; and 3) no change in the amount of 5-HT released in the hippocampus in response to electrical stimulation (5 Hz) of either the dorsal or median raphe nucleus, buta marked reduction in the amount of 5-HT released in the frontal cortex after electrical stimulation of the dorsal raphe nucleus. In summary, although MDMA causes marked 5-HT neurotoxicity, our data suggest that 5-HT cell firing is unchanged and, furthermore, that 5-HT release is maintained in some (but not all) forebrain regions even in response to physiological levels of stimulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 10:14:09