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Titolo:
THE DIAB-HYCAR STUDY
Autore:
PASSA P; CHATELLIER G;
Indirizzi:
HOP ST LOUIS,DEPT DIABET,1 AVE CLAUDE VELLEFAUX F-75475 PARIS 10 FRANCE HOP BROUSSAIS,DEPT MED INFORMAT PARIS FRANCE
Titolo Testata:
Diabetologia
fascicolo: 12, volume: 39, anno: 1996,
pagine: 1662 - 1667
SICI:
0012-186X(1996)39:12<1662:TDS>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR HYPERTROPHY; GENERAL-PRACTICE; RISK-FACTORS; MORTALITY; MICROALBUMINURIA; NIDDM; PROTEINURIA; PREDICTOR;
Keywords:
NIDDM; MICROALBUMINURIA; PROTEINURIA; ACE-INHIBITION; CARDIOVASCULAR MORBIDITY AND MORTALITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
P. Passa e G. Chatellier, "THE DIAB-HYCAR STUDY", Diabetologia, 39(12), 1996, pp. 1662-1667

Abstract

Microalbuminuria and proteinuria are strong independent predictors for increased cardiovascular mortality in non-insulin-dependent diabetic(NIDDM) patients. In such patients, angiotensin converting enzyme (ACE) inhibition improves the evolution of diabetic nephropathy; however,no data are currently available on the effects of such intervention on cardiovascular morbidity and mortality. The aim of the Diab-Hycar study is to test the hypothesis that ACE inhibition with a low daily dose of 1.25 mg ramipril, which has no significant effect on blood pressure, may reduce cardiovascular morbidity and/or mortality in normotensive or hypertensive NIDDM patients with persistent albuminuria. Selected and followed by general practitioners, 4000 patients will receive their usual oral antidiabetic treatment and if necessary antihypertensive treatment (ACE inhibitors excluded). In addition in a randomized, double-blind trial they will be given either a placebo or 1.25 mg ramipril daily. The follow-up is currently scheduled to last 3 years. The efficacy of ACE-inhibition will be assessed by the following major end-points: cardiovascular death, sudden death, myocardial infarction, stroke, renal replacement therapy. The Diab-Hycar study started on 3 February 1995. By 1 September 1995, 11 000 urine samples were tested. The prevalence of persistent albuminuria was 23 %, 964 patients were initially included in the study, with 619 eligible patients included soon after. Different strategies have been developed to record cardiovascularevents correctly and to minimize the number of patients lost to follow-up.

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Documento generato il 29/03/20 alle ore 17:36:00