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Titolo:
LOW-BIRTH-WEIGHT - IS IT ASSOCIATED WITH FEW AND SMALL GLOMERULI IN NORMAL SUBJECTS AND NIDDM PATIENTS
Autore:
NYENGAARD JR; BENDTSEN TF; MOGENSEN CE;
Indirizzi:
AARHUS UNIV,STEREOL RES LAB,BARTHOLIN BLDG DK-8000 AARHUS DENMARK AARHUS KOMMUNE HOSP,MED DEPT M AARHUS DENMARK
Titolo Testata:
Diabetologia
fascicolo: 12, volume: 39, anno: 1996,
pagine: 1634 - 1637
SICI:
0012-186X(1996)39:12<1634:L-IIAW>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMPAIRED GLUCOSE-TOLERANCE; ADULT HYPERTENSION; ARBITRARY PARTICLES; BLOOD-PRESSURE; INFANT GROWTH; FETAL GROWTH; NUMBER; SIZE; AGE; ENVIRONMENT;
Keywords:
BIRTH WEIGHT; DIABETES MELLITUS; GLOMERULUS; KIDNEY; STEREOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
J.R. Nyengaard et al., "LOW-BIRTH-WEIGHT - IS IT ASSOCIATED WITH FEW AND SMALL GLOMERULI IN NORMAL SUBJECTS AND NIDDM PATIENTS", Diabetologia, 39(12), 1996, pp. 1634-1637

Abstract

These studies were undertaken to ascertain if there is any association between low birth weight, and low kidney weight, few and/or small glomeruli, in kidneys from a control group and a group of non-insulin-dependent diabetic (NIDDM) patients. The background for this study comesfrom findings suggesting a correlation between low birth weight and the development of NIDDM and high blood pressure. Furthermore, Brenner has postulated that humans born with a low number of glomeruli, thereby having a low glomerular filtration surface area, have a greater tendency to develop high blood pressure. We examined 79 autopsy kidneys, with known weight from normal and NIDDM patients, which had previously been used for studies of glomerular number and volume. In the archivesof the Danish midwives we were able to find birth weight for 26 NIDDMpatients and an age- and sex-matched sample of 19 control persons. The kidney weight (g) (Control: 137 +/- 36; NIDDM: 150 +/- 38; 2p = 0.26), glomerular number (10(3)) (Control: 670 +/- 176; NIDDM: 673 +/- 200; 2p = 0.95), glomerular volume (10(6) mu m(3)) (Control: 6.25 +/- 1.48; NIDDM: 5.71 +/- 1.74; 2p = 0.28) or birth weight (g) (Control: 3577+/- 400; NIDDM: 3489 +/- 429; 2p = 0.49) were not different between the groups. There was no significant correlation between birth weight and glomerular number (Control: 2p = 0.80; r = 0.06 and NIDDM: 2p = 0.10; r = -0.33), glomerular volume (Control: 2p = 0.43; r = 0.19 and NIDDM: 2p = 0.78; r = 0.06) or kidney weight (Control: 2p = 0.56; r = 0.14 and NIDDM: 2p = 0.81; r = 0.05). Our results on a limited number of subjects in Denmark do not support the hypothesis that there is any association between low birth weight and low kidney weight or low birth weight and few and/or small glomeruli in NIDDM patients.

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Documento generato il 01/12/20 alle ore 16:01:36