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Titolo:
REPRODUCIBILITY OF REGIONAL BRAIN METABOLIC RESPONSES TO LORAZEPAM
Autore:
WANG GJ; VOLKOW ND; OVERALL J; HITZEMANN RJ; PAPPAS N; PASCANI K; FOWLER JS;
Indirizzi:
BROOKHAVEN NATL LAB,DEPT MED UPTON NY 11973 BROOKHAVEN NATL LAB,DEPT CHEM UPTON NY 11973 SUNY STONY BROOK,DEPT PSYCHIAT STONY BROOK NY 11794 SUNY STONY BROOK,DEPT RADIOL STONY BROOK NY 11794 UNIV TEXAS,DEPT PSYCHIAT & BEHAV SCI HOUSTON TX 00000 VET ADM MED CTR,PSYCHIAT SERV NORTHPORT NY 11768
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 10, volume: 37, anno: 1996,
pagine: 1609 - 1613
SICI:
0161-5505(1996)37:10<1609:RORBMR>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; GLUCOSE-METABOLISM; ALCOHOLICS; DIAZEPAM; VARIABILITY; ANXIETY;
Keywords:
CEREBRAL GLUCOSE METABOLISM; LORAZEPAM; PHARMACOLOGICAL CHALLENGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
G.J. Wang et al., "REPRODUCIBILITY OF REGIONAL BRAIN METABOLIC RESPONSES TO LORAZEPAM", The Journal of nuclear medicine, 37(10), 1996, pp. 1609-1613

Abstract

Changes in regional brain glucose metabolism in response to benzodiazepine agonists have been used as indicators of benzodiazepine-GABA receptor function. The purpose of this study was to assess the reproducibility of these responses. Methods: Sixteen healthy right-handed men underwent scanning with PET and [F-18]fluorodeoxyglucose (FDG) twice: before placebo and before lorazepam (30 mu g/kg). The same double FDG procedure was repeated 6-8 wk later on the men to assess test-retest reproducibility. Results: The regional absolute brain metabolic values obtained during the second evaluation were significantly lower than those obtained from the first evaluation regardless of condition (p less than or equal to 0.001). Lorazepam significantly and consistently decreased both whole-brain metabolism and the magnitude. The regional pattern of the changes were comparable for both studies (12.3% +/- 6.9% and13.7% +/- 7.4%). Lorazepam effects were the largest in the thalamus (22.2% +/- 8.6% and 22.4% +/- 6.9%) and occipital cortex (19% +/- 8.9% and 21.8% +/- 8.9%). Relative metabolic measures were highly reproducible both for pharmacolgic and replication condition. Conclusion: This study measured the test-retest reproducibility in regional brain metabolic responses, and although the global and regional metabolic values were significantly lower for the repeated evaluation, the response to lorazepam was highly reproducible.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 20:13:11