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Titolo:
COMPARISON OF IODINE-123-EPIDEPRIDE AND IODINE-123-IBZM FOR DOPAMINE D2 RECEPTOR IMAGING
Autore:
LESLIE WD; ABRAMS DN; GREENBERG CR; HOBSON D;
Indirizzi:
ST BONIFACE GEN HOSP,DEPT INTERNAL MED C5121,409 TACHE AVE WINNIPEG MB R2H 2A6 CANADA UNIV MANITOBA,DEPT NUCL MED WINNIPEG MB CANADA UNIV MANITOBA,DEPT HUMAN GENET WINNIPEG MB CANADA UNIV MANITOBA,DEPT NEUROL WINNIPEG MB CANADA
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 10, volume: 37, anno: 1996,
pagine: 1589 - 1591
SICI:
0161-5505(1996)37:10<1589:COIAIF>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPRANUCLEAR PALSY; I-125 EPIDEPRIDE; HUMAN BRAIN; SPECT; INVIVO; DISEASE; AGENT; TOMOGRAPHY; IBZM;
Keywords:
NEUROIMAGING; NEUROTRANSMITTER; DOPAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
W.D. Leslie et al., "COMPARISON OF IODINE-123-EPIDEPRIDE AND IODINE-123-IBZM FOR DOPAMINE D2 RECEPTOR IMAGING", The Journal of nuclear medicine, 37(10), 1996, pp. 1589-1591

Abstract

Although (123)1-IBZM is widely used as a D2 receptor imaging agent, image quality is compromised by a relatively low target-to-nontarget ratio. Animal studies suggest that I-123-epidepride (K-d 0.024 nM) may be superior to I-123-IBZM, but this agent has not been systematically studied in humans. Methods: We directly compared I-123-epidepride and I-123-IBZM in five normal volunteers (age range 30-58 yr, mean 43 yr). Brain SPECT imaging was performed 2 hr after the I-123-IBZM injection (average dose 153 MBq). lodine-123-epidepride scans were performed 1 hr (n = 3), 2 hr (n = 5) and 3 hr (n = 3) postinjection (average dose 149 MBq). Results: Both radiopharmaceuticals were well tolerated. Iodine-123-epidepride provided excellent visualization of the striatum. Percent specific striatum uptake at 2 hr (71.7 +/- 4.9%) was much greaterthan with I-123-IBZM (32.6 +/- 5.3%, p < 0.01). Conclusion: lodine-123-epidepride is a new D2 receptor agent that exhibits excellent neuroimaging properties and has a much higher affinity for striatal uptake than I-123-IBZM.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/12/19 alle ore 11:45:45