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Titolo:
DOPAMINE D2 RECEPTOR DIMERS AND RECEPTOR-BLOCKING PEPTIDES
Autore:
NG GYK; ODOWD BF; LEE SP; CHUNG HT; BRANN MR; SEEMAN P; GEORGE SR;
Indirizzi:
UNIV TORONTO,DEPT PHARMACOL,MED SCI BLDG,RM 4358,8 TADDLE CREEK RD TORONTO ON M5S 1A8 CANADA UNIV TORONTO,DEPT PSYCHIAT TORONTO ON M5S 1A8 CANADA UNIV TORONTO,DEPT MED TORONTO ON M5S 1A8 CANADA ADDICT RES FDN TORONTO ON M5S 2S1 CANADA UNIV VERMONT,SCH MED,DEPT PSYCHIAT BURLINGTON VT 05405 UNIV VERMONT,SCH MED,DEPT PHARMACOL BURLINGTON VT 05405
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 1, volume: 227, anno: 1996,
pagine: 200 - 204
SICI:
0006-291X(1996)227:1<200:DDRDAR>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; NAIVE SCHIZOPHRENIC-PATIENTS; C-11 N-METHYLSPIPERONE; SF9 CELLS; PHOSPHORYLATION; PALMITOYLATION; DENSITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
G.Y.K. Ng et al., "DOPAMINE D2 RECEPTOR DIMERS AND RECEPTOR-BLOCKING PEPTIDES", Biochemical and biophysical research communications, 227(1), 1996, pp. 200-204

Abstract

Dopamine D2 receptors exist as dimers in whole cell lysate, crude membranes prepared from human caudate, and following solubilization and immunoprecipitation of the receptor from these tissues. Photoaffinity labelling experiments confirmed that D2 receptors exist either as monomers that are selective targets for spiperone or as dimers that are targets for nemonapride. incubation of D2 dimers with peptides derived from the putative transmembrane (TM) domains of the D2 receptor, or incubation under high temperatures or low pH resulted in the dissociation of the dimer to monomer. D2-TM peptides were unable to dissociate dopamine D1 and serotonin 5-HT1B receptor dimers, suggesting that receptordimers are formed by specific intermolecular noncovalent interactionsinvolving TM regions. This opens a path to new selective therapeutic receptor-blocking compounds based on this principle of mimicking transmembrane portions of neurotransmitter receptors. (C) 1996 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:11:29