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Titolo:
EFFECTS OF THE PCP ANALOG DIZOCILPINE ON SENSORY GATING - POTENTIAL RELEVANCE TO CLINICAL SUBTYPES OF SCHIZOPHRENIA
Autore:
ALAMIN HA; SCHWARZKOPF SB;
Indirizzi:
UNIV ROCHESTER,SCH MED,DEPT PSYCHIAT,MELIORA HALL ROOM 171 ROCHESTER NY 14627 UNIV ROCHESTER,SCH MED,DEPT PSYCHIAT ROCHESTER NY 14627
Titolo Testata:
Biological psychiatry
fascicolo: 8, volume: 40, anno: 1996,
pagine: 744 - 754
SICI:
0006-3223(1996)40:8<744:EOTPAD>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
APPARENT ANXIOLYTIC PROPERTIES; WEAK PRE-STIMULATION; STARTLE RESPONSE; ACOUSTIC STARTLE; PREPULSE INHIBITION; 10-IMINE MK-801; ANIMAL-MODEL; RAT; REFLEX; PHENCYCLIDINE;
Keywords:
DIZOCILPINE; PREPULSE INHIBITION; PREPULSE FACILITATION; ACOUSTIC STARTLE REFLEX; ANIMAL MODELS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
H.A. Alamin e S.B. Schwarzkopf, "EFFECTS OF THE PCP ANALOG DIZOCILPINE ON SENSORY GATING - POTENTIAL RELEVANCE TO CLINICAL SUBTYPES OF SCHIZOPHRENIA", Biological psychiatry, 40(8), 1996, pp. 744-754

Abstract

Prepulse inhibition (PPI) of the acoustic startle reflex, a measure of sensory gating, is reduced is schizophrenic patients. Dopamine agonists and NMDA receptor antagonists such as phencyclidine (PCP) can disrupt PPI in animals, consistent with both the dopamine and glutamate hypotheses of schizophrenia. In this study, we sought to further characterize the effects of the NMDA antagonist dizocilpine on acoustic startle modulation. Fischer 344 rats were tested after one of three doses of dizocilpine (0.05, 0.2, and 0.5 mg/kg) and assessed for PPI as well as for alterations in baseline startle and prepulse facilitation (PPF). Results showed complete disruption of PPI for each inhibitory trial type after 0.2 and 0.5 mg/kg of dizocilpine. Baseline startle and PPF were enhanced by the low dose but decreased with the moderate and highdoses of dizocilpine. Although dizocilpine caused alterations in prepulse modulation of startle similar to dopamine agonists, some effects differ. Unique effects of dizocilpine on sensory gating are discussed in terms of their potential for discriminating subtypes of schizophrenic illness with different underlying pathophysiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 04:11:56