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Titolo:
THE EFFECTS OF PHOSPHORYLATION ON THE FUNCTIONAL REGULATION OF AN EXPRESSED RECOMBINANT HUMAN DOPAMINE TRANSPORTER
Autore:
VRINDAVANAM NS; ARNAUD P; MA JX; ALTMANHAMAMDZIC S; PARRATTO NP; SALLEE FR;
Indirizzi:
MED UNIV S CAROLINA,DEPT PSYCHIAT & BEHAV SCI,171 ASHLEY AVE CHARLESTON SC 29425 MED UNIV S CAROLINA,DEPT PSYCHIAT & BEHAV SCI CHARLESTON SC 29425 MED UNIV S CAROLINA,DEPT MICROBIOL & IMMUNOL CHARLESTON SC 29425 MED UNIV S CAROLINA,STORM EYE INST CHARLESTON SC 29425
Titolo Testata:
Neuroscience letters
fascicolo: 2, volume: 216, anno: 1996,
pagine: 133 - 136
SICI:
0304-3940(1996)216:2<133:TEOPOT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLONING; PROGRESS; RELEASE; NEURONS;
Keywords:
DOPAMINE TRANSPORTER; METABOLIC LABELING; PHOSPHORYLATION; FUNCTIONAL REGULATION; UPTAKE; BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
N.S. Vrindavanam et al., "THE EFFECTS OF PHOSPHORYLATION ON THE FUNCTIONAL REGULATION OF AN EXPRESSED RECOMBINANT HUMAN DOPAMINE TRANSPORTER", Neuroscience letters, 216(2), 1996, pp. 133-136

Abstract

Metabolic labeling experiments were performed using eukaryotic cells transfected with the human dopamine (DA) transporter cDNA. Autophosphorylation in the presence and absence of the transporter substrate DA, was analyzed. Dopamine transporter (DAT) was phosphorylated in the absence of DA and dephosphorylated in the presence of the substrate. The functional significance of this phenomenon was checked by incubating cells with phosphorylation promoting agents, all of which reduced substrate uptake and ligand binding significantly. It is shown that at least one site of phosphorylation on DAT is a serine residue. These experiments suggest that the state of phosphorylation of the DAT may play animportant role in its biological function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:34:41