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Titolo:
ALTERATION OF RYANODINE RECEPTOR IN THE HIPPOCAMPUS CA1 AFTER HEMISPHERIC CEREBRAL-ISCHEMIA
Autore:
NOZAKI H; TANAKA K; GOMI S; MIHARA B; NOGAWA S; NAGATA E; KONDO T; FUKUUCHI Y;
Indirizzi:
KEIO UNIV,SCH MED,DEPT NEUROL,SHINJUKU KU,35 SHINANOMACHI TOKYO 160 JAPAN MIHARA MEM HOSP,DEPT NEUROL ISESAKI GUMMA 372 JAPAN
Titolo Testata:
Neurochemical research
fascicolo: 8, volume: 21, anno: 1996,
pagine: 975 - 982
SICI:
0364-3190(1996)21:8<975:AORRIT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSCLE SARCOPLASMIC-RETICULUM; DEPENDENT PROTEIN-KINASE; CALCIUM-RELEASE CHANNEL; CYCLIC ADP-RIBOSE; GERBIL BRAIN; SKELETAL-MUSCLE; BLOOD-FLOW; AUTORADIOGRAPHIC ANALYSIS; 2ND-MESSENGER SYSTEMS; DANTROLENE SODIUM;
Keywords:
RYANODINE; CEREBRAL ISCHEMIA; 2ND MESSENGER; CA2+; HIPPOCAMPUS; CEREBRAL BLOOD FLOW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
H. Nozaki et al., "ALTERATION OF RYANODINE RECEPTOR IN THE HIPPOCAMPUS CA1 AFTER HEMISPHERIC CEREBRAL-ISCHEMIA", Neurochemical research, 21(8), 1996, pp. 975-982

Abstract

Alterations in ryanodine binding and local cerebral blood flow (LCBF)were examined at 30 minutes and 2 hours post-ischemia in the gerbil brain in order to evaluate the influence of cerebral ischemia on the intracellular channels of Ca2+-induced Ca2+ release (CICR). Severe hemispheric cerebral ischemia was induced by occluding the right common carotid artery. LCBF was measured at the end of the experiment using [C-14]iodoantipyrine method, and the ryanodine binding was evaluated in vitro using [H-3]ryanodine as a specific ligand for CICR channels. An autoradiographic method developed in our laboratory enabled us to determine both parameters within the same brain. A group of gerbils who underwent a sham procedure served as controls. LCBF was found to be significantly reduced in most of the cerebral regions on the occluded side at both 30 minutes as well as 2 hours post-ischemia. In contrast, a significant reduction in ryanodine binding was noted only in the hippocampus CA1 on the occluded side at 30 minutes and 2 hours after the occlusion These findings suggest that regionally specific changes of CICR may be the cause of decreased ryanodine binding in the hippocampus CA1,and that these changes may be related to the pathophysiological mechanisms that cause this region to be particularly vulnerable to ischemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 15:57:50