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Titolo:
ISCHEMIA-REPERFUSION INJURY IN THE SPINAL-CORD OF RABBITS STRONGLY ENHANCES LIPID-PEROXIDATION AND MODIFIES PHOSPHOLIPID PROFILES
Autore:
LUKACOVA N; HALAT G; CHAVKO M; MARSALA J;
Indirizzi:
SLOVAK ACAD SCI,DEPT NEUROCHEM,INST NEUROBIOL,SOLTESOVEJ 4,6 KOSICE 04000 SLOVAKIA
Titolo Testata:
Neurochemical research
fascicolo: 8, volume: 21, anno: 1996,
pagine: 869 - 873
SICI:
0364-3190(1996)21:8<869:IIITSO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVOUS-SYSTEM TRAUMA; RAT-BRAIN; POSTISCHEMIC REPERFUSION; INCOMPLETE ISCHEMIA; GLOBAL-ISCHEMIA; FATTY-ACIDS; INVOLVEMENT; STROKE; DAMAGE; GERBIL;
Keywords:
SPINAL CORD ISCHEMIA; LIPID PEROXIDATION; PHOSPHOLIPIDS; POSTISCHEMIC REPERFUSION; RABBIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
N. Lukacova et al., "ISCHEMIA-REPERFUSION INJURY IN THE SPINAL-CORD OF RABBITS STRONGLY ENHANCES LIPID-PEROXIDATION AND MODIFIES PHOSPHOLIPID PROFILES", Neurochemical research, 21(8), 1996, pp. 869-873

Abstract

The effect of spinal cord ischemia (10, 20, and 40 min) and post-ischemic reperfusion (10, 30, and 60 min) on lipid peroxidation and phospholipids was investigated. Spinal cord ischemia was accompanied by lipolytic processes with significant changes in concentration of lipid peroxidation products (LPP). Reestablishment of the blood supply after 10min ischemia was accompanied by significantly increased levels of thiobarbituric acid reactive substances (TBA-RS) after 10 and 30 min of reperfusion. Following 20 and 40 min ischemia a significant increase was observed at all reperfusion periods. Ischemia itself significantly reduced the concentration of phosphatidyl inositol (IP), phosphatidyl ethanolamine (EP) and ethanolamine plasmalogens (Epls). Significant changes were observed in concentration of phosphatidyl serine (SP) too, but only after 20 and 40 min of ischemia. The concentration of phosphatidic acid (PA) was significantly reduced only after 10 min of ischemiaThe onset of reperfusion after ischemia was accompanied by a diverse pattern of changes in PA, IP, Epls and SP, while the concentration of EP remained at the above mentioned ischemic intervals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 01:17:13