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Titolo:
RECORDING FROM THE INFERIOR COLLICULUS FOLLOWING COCHLEAR INNER HAIR CELL-DAMAGE
Autore:
WAKE M; TAKENO S; MOUNT RJ; HARRISON RV;
Indirizzi:
ROYAL HOSP WOLVERHAMPTON,DEPT OTORHINOLARYNGOL HEAD & NECK SURG WOLVERHAMPTON WV10 0QP ENGLAND DUDLEY RD GEN HOSP WOLVERHAMPTON WV10 0QP ENGLAND HIROSHIMA UNIV,DEPT OTORHINOLARYNGOL HIROSHIMA JAPAN UNIV TORONTO,HOSP SICK CHILDREN,AUDITORY SCI LAB TORONTO ON M5G 1X8 CANADA
Titolo Testata:
Acta oto-laryngologica
fascicolo: 5, volume: 116, anno: 1996,
pagine: 714 - 720
SICI:
0001-6489(1996)116:5<714:RFTICF>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
STEREOCILIA DAMAGE; CAT; CARBOPLATIN; OTOTOXICITY; THRESHOLD; PATHOLOGY;
Keywords:
CARBOPLATIN; INFERIOR COLLICULUS; SINGLE UNIT RECORDING; COCHLEAR HAIR CELLS; OTOTOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
M. Wake et al., "RECORDING FROM THE INFERIOR COLLICULUS FOLLOWING COCHLEAR INNER HAIR CELL-DAMAGE", Acta oto-laryngologica, 116(5), 1996, pp. 714-720

Abstract

The anti-cancer drug carboplatin has been used to generate inner haircell (IHC) lesions in the cochleae of chinchilla. This model has provided a valuable physiological tool for the study of the auditory system, particularly concerning the relative roles of IHCs and outer hair cells (OHCs). We recorded responses to contralateral sound stimuli of single units (SU) in the central nucleus (CN) of the inferior colliculus (IC) from normal and carboplatin treated animals. Normal single unitthresholds and frequency tuning curves (FTCs) were found, despite gross IHC damage within the cochleae of carboplatin treated animals. No evoked afferent responses could he detected in CN regions which represented cochlear loci where total MC loss had occurred. Normal frequency selectivity in the auditory system is possible with small numbers of surviving IHCs provided OHCs remain normal.

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Documento generato il 25/11/20 alle ore 07:09:14