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Titolo:
UPTAKE OF IODINE-123-ALPHA-METHYL TYROSINE BY GLIOMAS AND NONNEOPLASTIC BRAIN-LESIONS
Autore:
KUWERT T; MORGENROTH C; WOESLER B; MATHEJA P; PALKOVIC S; VOLLET B; SAMNICK S; MAASJOSTHUSMANN U; LERCH H; GILDENHAUS FJ; WASSMANN H; SCHOBER O;
Indirizzi:
UNIV MUNSTER,DEPT NUCL MED,ALBERT SCHWEITZER STR 33 D-48129 MUNSTER GERMANY UNIV MUNSTER,DEPT NEUROSURG D-4400 MUNSTER GERMANY
Titolo Testata:
European journal of nuclear medicine
fascicolo: 10, volume: 23, anno: 1996,
pagine: 1345 - 1353
SICI:
0340-6997(1996)23:10<1345:UOITBG>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; AMINO-ACID-TRANSPORT; F-18 FLUORODEOXYGLUCOSE; COMPUTED-TOMOGRAPHY; CEREBRAL GLIOMAS; L-3-)I-123>IODO-ALPHA-METHYL TYROSINE; PET; TUMORS; DIAGNOSIS; SPECT;
Keywords:
BRAIN NEOPLASMS; AMINO ACIDS; IODINE-123-ALPHA-METHYL TYROSINE; RADIONUCLIDE IMAGING; SINGLE-PHOTON EMISSION TOMOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
T. Kuwert et al., "UPTAKE OF IODINE-123-ALPHA-METHYL TYROSINE BY GLIOMAS AND NONNEOPLASTIC BRAIN-LESIONS", European journal of nuclear medicine, 23(10), 1996, pp. 1345-1353

Abstract

Using single-photon emission tomography (SPET), the radiopharmaceutical L-3-iodine-123-alpha-methyl tyrosine (IMT) has been applied to the imaging of amino acid transport into brain tumours. It was the aim of this study to investigate whether IMT SPET is capable of differentiating between high-grade gliomas, low-grade gliomas and non-neoplastic brain lesions. To this end, IMT uptake was determined in 53 patients using the triple-headed SPET camera MULTISPECT 3. Twenty-eight of these subjects suffered from high-grade gliomas (WHO grade III or IV), 12 from low-grade gliomas (WHO grade II), and 13 from non-neoplastic brain lesions, including lesions after effective therapy of a glioma (five cases), infarctions (four cases), inflammatory lesions (three cases) andtraumatic haematoma (one case). IMT uptake was significantly higher in high-grade gliomas than in low-grade gliomas and non-neoplastic lesions. IMT uptake by low-grade gliomas was not significantly different from that by non-neoplastic lesions. Diagnostic sensitivity and specificity were 71% and 83% for differentiating high-grade from low-grade gliomas, 82% and 100% for distinguishing high-grade gliomas from non-neoplastic lesions, and 50% and 100% for discriminating low-grade gliomasfrom non-neoplastic lesions. Analogously to positron emission tomography with radioactively labelled amino acids and fluorine-ls deoxyglucose, IMT SPET may aid in differentiating high-grade gliomas from histologically benign brain tumours and non-neoplastic brain lesions; it is of only limited value in differentiating between non-neoplastic lesions and histologically benign brain tumours.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/21 alle ore 05:26:22