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Titolo:
CENTRAL ACTIONS OF CORTICOTROPIN-RELEASING FACTOR ON SENSORI-AUTONOMIC PROCESSING IN NORMOTENSIVE AND HYPERTENSIVE RATS
Autore:
YOUNGBLOOD K; CONTI L; PRINTZ MP;
Indirizzi:
UNIV CALIF SAN DIEGO,DEPT PHARMACOL SAN DIEGO CA 92121 UNIV CALIF SAN DIEGO,DEPT PSYCHIAT SAN DIEGO CA 92121
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 734, anno: 1996,
pagine: 175 - 185
SICI:
0006-8993(1996)734:1-2<175:CAOCFO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCUS COERULEUS NEURONS; ACOUSTIC STARTLE REFLEX; BEHAVIORAL-RESPONSES; FACTOR CRF; HEART-RATE; CARDIOVASCULAR FUNCTION; ALERTING STIMULI; CONSCIOUS RATS; BRAIN; STRESS;
Keywords:
CARDIOVASCULAR; CORTICOTROPIN-RELEASING FACTOR; HYDRALAZINE; SPONTANEOUSLY HYPERTENSIVE RAT; WISTAR-KYOTO RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
K. Youngblood et al., "CENTRAL ACTIONS OF CORTICOTROPIN-RELEASING FACTOR ON SENSORI-AUTONOMIC PROCESSING IN NORMOTENSIVE AND HYPERTENSIVE RATS", Brain research, 734(1-2), 1996, pp. 175-185

Abstract

The airpuff startle paradigm, a stress paradigm, elicits greater presser and tachycardia responses in SHR(LJ) than WKYLJ which, unlike SHR(LJ), also show bradycardia. CRF has been implicated in coordinating autonomic responses to stressors. The present studies explored the role of CRF, CRF antagonist D-PheCRF(12-41) and chronic hydralazine in stress-induced cardiovascular responses. In SHR(LJ) CRF unmasked a bradycardia response, equal to WKYLJ receiving either aCSF or CRF, which was blocked by D-PheCRF(12-41). CRF given to hydralazine-treated SHR(LJ) did nor unmask a bradycardia. In WKYLJ, CRF specifically lowered the presser response on trial 1 compared to control, an effect abolished by the antagonist. WKYLJ receiving D-PheCRF(12-41) prior to testing showed greater presser and bradycardia responses when compared to control. In the WKYLJ CRF appears to exert an inhibitory role on the presser and bradycardia responses while in the SHR(LJ) CRF exerts a permissive role on the bradycardia response which is lost when blood pressure is normalized with chronic hydralazine. CRF and D-PheCRF(12-41) modify stress-induced cardiovascular responses in a strain-dependent dissimilar fashion. We conclude CRF has cardiovascular importance in the genetic hypertensive rat.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 06:25:06