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Titolo:
ANALYSIS OF THE CONTRIBUTION OF HLA GENES TO GENETIC PREDISPOSITION IN INFLAMMATORY BOWEL-DISEASE
Autore:
NAOM I; LEE J; FORD D; BOWMAN SJ; LANCHBURY JS; HARIS I; HODGSON SV; EASTON D; LENNARDLONES J; MATHEW CG;
Indirizzi:
UNITED MED & DENT SCH,GUYS HOSP,DIV MED & MOL GENET,8TH FLOOR GUYS TOWER LONDON SE1 9RT ENGLAND UNITED MED & DENT SCH,GUYS HOSP,DIV MED & MOL GENET LONDON SE1 9RT ENGLAND UNITED MED & DENT SCH,GUYS HOSP,MOL IMMUNOGENET UNIT LONDON ENGLAND ST MARKS HOSP LONDON EC1V 2PS ENGLAND INST CANC RES,EPIDEMIOL SECT SUTTON SURREY ENGLAND
Titolo Testata:
American journal of human genetics
fascicolo: 1, volume: 59, anno: 1996,
pagine: 226 - 233
SICI:
0002-9297(1996)59:1<226:AOTCOH>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLEX SEGREGATION ANALYSIS; ULCERATIVE-COLITIS; CROHNS-DISEASE; MULTIPLE SIBLINGS; LINKAGE; JAPANESE; PREVALENCE; STRATEGIES; ANTIGEN; FAMILY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
I. Naom et al., "ANALYSIS OF THE CONTRIBUTION OF HLA GENES TO GENETIC PREDISPOSITION IN INFLAMMATORY BOWEL-DISEASE", American journal of human genetics, 59(1), 1996, pp. 226-233

Abstract

Crohn disease (CD) and ulcerative colitis (UC) are chronic inflammatory bowel diseases (IBDs) of unknown etiology. First-degree relatives of LED patients have a 10-fold increase in risk of developing the same disease, and distinct associations between specific HLA types and bothCD and UC have been reported. We have evaluated the contribution of genes at the HLA locus to susceptibility in IBD by linkage analysis of highly informative microsatellite polymorphisms in 43 families with multiple affected cases. No evidence for linkage of HLA to IBD was obtained under any of the four models tested. Analysis of HLA haplotype sharing in affected relatives indicated that the relative risk to a sibling conferred by the HLA locus was 1.11 in UC and 0.75 in CD, with upper (95%) confidence limits of 2.41 and 1.37, respectively. This suggests that other genetic or environmental factors are responsible for mostof the familial aggregation in LED.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 09:06:15