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Titolo:
INFERTILITY AND CELIAC-DISEASE
Autore:
COLLIN P; VILSKA S; HEINONEN PK; HALLSTROM O; PIKKARAINEN P;
Indirizzi:
UNIV TAMPERE,SCH MED,POB 607 FIN-33101 TAMPERE FINLAND TAMPERE UNIV HOSP,DEPT MED TAMPERE FINLAND TAMPERE UNIV HOSP,DEPT OBSTET & GYNAECOL TAMPERE FINLAND TAMPERE UNIV HOSP,DEPT MICROBIOL TAMPERE FINLAND
Titolo Testata:
Gut
fascicolo: 3, volume: 39, anno: 1996,
pagine: 382 - 384
SICI:
0017-5749(1996)39:3<382:IAC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELIAC-DISEASE; DERMATITIS-HERPETIFORMIS; ANTIGLIADIN ANTIBODIES; GYNECOLOGICAL PROBLEMS; IGA-CLASS; SPRUE;
Keywords:
CELIAC DISEASE; INFERTILITY; GLIADIN ANTIBODIES; RETICULIN ANTIBODIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
P. Collin et al., "INFERTILITY AND CELIAC-DISEASE", Gut, 39(3), 1996, pp. 382-384

Abstract

Background-Coeliac women may suffer from gynaecological and obstetriccomplications. It is possible that these complications are the first symptom of coeliac disease. Aims-To investigate the occurrence of subclinical coeliac disease in patients with infertility or recurrent miscarriages. Subjects-Women of reproductive age who were attending the hospital because of either primary or secondary infertility, or two or more miscarriages. Women undergoing sterilisation served as control subjects. Methods-The diagnostic investigation for infertility included the endocrine status, diagnostic laparoscopy, investigation of tubal patency, postcoital test, and semen analysis of the partner. Circulatingantibodies against IgA class reticulin and gliadin were used in screening for coeliac disease. In positive cases, the diagnosis was confirmed by small bowel biopsy specimens. Results-Four (2.7%) of 150 women in the infertility group, and none of the 150 control subjects were found to have coeliac disease (p=0.06). All four women with coeliac disease suffered from infertility of unexplained origin. Altogether 98 women had no discoverable reason for infertility. Thus, in this subgroup the frequency of coeliac disease was 4.1% (four of 98), the difference from the control group being statistically significant (p=0.02). None of the coeliac women had extensive malabsorption, but two had iron deficiency anaemia. One women with coeliac disease has had a normal delivery. None of the 50 women with miscarriage had coeliac disease. Conclusion-Patients having fertility problems may have subclinical coeliac disease, which can be detected by serological screening tests. Silent coeliac disease should be considered in the case of women with unexplained infertility.

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Documento generato il 21/09/20 alle ore 06:08:16