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Titolo:
DEVELOPMENT OF DONOR-DERIVED PROSTATE-CANCER IN A RECIPIENT FOLLOWINGORTHOTOPIC HEART-TRANSPLANTATION
Autore:
LOH E; COUCH FJ; HENDRICKSEN C; FARID L; KELLY PF; ACKER MA; TOMASZEWSKI JE; MALKOWICZ SB; WEBER BL;
Indirizzi:
UNIV PENN,SCH MED,DEPT MED,STELLAR CHANCE LABS,422 CURIE BLVD,ROOM 1009 PHILADELPHIA PA 19104 UNIV PENN,SCH MED,DEPT MED,STELLAR CHANCE LABS PHILADELPHIA PA 19104 UNIV PENN,SCH MED,DEPT PATHOL PHILADELPHIA PA 19104 UNIV PENN,SCH MED,DEPT GENET PHILADELPHIA PA 19104 UNIV PENN,SCH MED,DEPT SURG PHILADELPHIA PA 19104
Titolo Testata:
JAMA, the journal of the American Medical Association
fascicolo: 2, volume: 277, anno: 1997,
pagine: 133 - 137
SICI:
0098-7484(1997)277:2<133:DODPIA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PATTERNS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
E. Loh et al., "DEVELOPMENT OF DONOR-DERIVED PROSTATE-CANCER IN A RECIPIENT FOLLOWINGORTHOTOPIC HEART-TRANSPLANTATION", JAMA, the journal of the American Medical Association, 277(2), 1997, pp. 133-137

Abstract

Objective.-To report the development of metastatic prostate cancer ina heart transplant recipient without a primary focus in the recipientprostate gland; to present genetic evidence suggesting transplantation of the malignancy from the donor. Design.-Histological analysis of donor prostate and recipient prostate and rib, Molecular genetic analysis of prostate and kidney tissue from the donor and peripheral blood leukocytes and rib tissue from the transplant recipient. Setting.-University of Pennsylvania Medical Center. Results.-Multiple biopsies of recipient prostate were negative for malignancy but recipient rib contained prostatic adenocarcinoma with osteoblastic bone response, Molecular genetic analysis of recipient rib specimen, which contained both histologically normal and neoplastic cells, was shown to contain a combination of alleles from the donor and recipient at 4 loci. Conclusion.-Although this is a single case report of an uncommon event, genotyping of polymorphic dinucleotide repeat elements from 4 different chromosomal regions provides strong evidence that the tumor cells arose from donor tissue and were transplanted along with the cardiac allograft.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 09:59:41