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Titolo:
ARTIFICIAL LIVER SUPPORT - STATE-OF-THE-ART
Autore:
DIXIT V; GITNICK G;
Indirizzi:
UNIV CALIF LOS ANGELES,SCH MED,DIV DIGEST DIS,DEPT MED LOS ANGELES CA90024 UNIV CALIF LOS ANGELES,SCH MED,DIV DIGEST DIS,DEPT MED LOS ANGELES CA90024
Titolo Testata:
Scandinavian journal of gastroenterology
, volume: 31, anno: 1996, supplemento:, 220
pagine: 101 - 114
SICI:
0036-5521(1996)31:<101:ALS-S>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICROCARRIER-ATTACHED HEPATOCYTES; EXPERIMENTAL HEPATIC-FAILURE; HYBRID BIOARTIFICIAL LIVER; GUNN-RATS; MICROENCAPSULATED HEPATOCYTES; ASSIST DEVICE; TRANSPLANTATION; CELLS; IMMUNOSUPPRESSION; MAINTENANCE;
Keywords:
ARTIFICIAL LIVER SUPPORT; BIOARTIFICIAL LIVER; BRIDGE TO TRANSPLANTATION; CELL (HEPATOCYTE) TRANSPLANTATION; HEPATOCYTE BIOREACTOR; ISOLATED ENCAPSULATED HEPATOCYTES; ISOLATED HEPATOCYTES; MICROENCAPSULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
74
Recensione:
Indirizzi per estratti:
Citazione:
V. Dixit e G. Gitnick, "ARTIFICIAL LIVER SUPPORT - STATE-OF-THE-ART", Scandinavian journal of gastroenterology, 31, 1996, pp. 101-114

Abstract

Severe liver disease is very often life-threatening and dramatically diminishes quality of life. Liver support systems based on detoxification alone have proven ineffective because they cannot correct biochemical disorders. An effective artificial liver support system should be capable of carrying out the liver's essential processes, such as synthetic and metabolic functions, detoxification, and excretion. It shouldbe capable of sustaining patients with fulminant hepatic failure, preparing patients for liver transplantation when a donor liver is not readily available (i.e., bridge to transplantation), and improving the survival and quality of life for patients for whom transplantation is not a therapeutic option. Recent advances in cell biology, tissue culture techniques, and biotechnology have led the way for the potential use of isolated hepatocytes in treating an array of liver disorders. Isolated hepatocytes may be transplanted to replace liver-specific deficiencies or as an important element of an auxiliary hybrid, bioartificial extracorporeal liver support device, which are important therapeuticapplications for treating severe liver disease. Although several hepatocyte-based liver support systems have been proposed, there is no current consensus on its eventual design configuration. Furthermore, application of tissue engineering technology, based on cell-surface interaction studies proposed by our group and others, has enhanced interest in the development of highly efficient hybrid, bioartificial, liver support devices.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/21 alle ore 14:56:41