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Titolo:
NEURONAL DIVERSITY IN THE SUBICULUM - CORRELATIONS WITH THE EFFECTS OF SOMATOSTATIN ON INTRINSIC-PROPERTIES AND ON GABA-MEDIATED IPSPS IN-VITRO
Autore:
GREENE JRT; MASON A;
Indirizzi:
UNIV OXFORD,DEPT PHARMACOL,MANSFIELD RD OXFORD OX1 3QT ENGLAND
Titolo Testata:
Journal of neurophysiology
fascicolo: 3, volume: 76, anno: 1996,
pagine: 1657 - 1666
SICI:
0022-3077(1996)76:3<1657:NDITS->2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT HIPPOCAMPAL SLICES; ORIENS-ALVEUS BORDER; CA1 PYRAMIDAL CELLS; IN-VITRO; GLUTAMATE STIMULATION; VENTRAL SUBICULUM; ENTORHINAL CORTEX; NUCLEUS-ACCUMBENS; MESSENGER-RNA; AREA CA1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
J.R.T. Greene e A. Mason, "NEURONAL DIVERSITY IN THE SUBICULUM - CORRELATIONS WITH THE EFFECTS OF SOMATOSTATIN ON INTRINSIC-PROPERTIES AND ON GABA-MEDIATED IPSPS IN-VITRO", Journal of neurophysiology, 76(3), 1996, pp. 1657-1666

Abstract

1. We used intracellular current-clamp techniques to record from 33 ventral subicular neurons in slices of rat hippocampal formation. Presumed pyramidal neurons were characterized by their responses to depolarizing current pulses as either intrinsically burst firing (IB) or regular spiking (RS). Within the subiculum, IB cells were encountered mostfrequently in the deep cell layer, whereas RS cells were encountered most frequently in the superficial cell layer. IB cells had more depolarized resting potentials, lower input resistances, and more sag in their voltage responses to hyperpolarizing current pulses. 2. Somatostatin (5 mu M) applied in the bathing medium caused a hyperpolarization and reduction in input resistance. These effects were of greater magnitude in IB cells. Somatostatin had no effect on sag in either cell type. These effects of somatostatin were unchanged in the presence of gamma-aminobutyric acid (GABA) receptor antagonists. 3. In a series of experiments conducted in RS cells only, somatostatin reduced the amplitude of the late but not the early component of evoked biphasic inhibitory postsynaptic potentials (IPSPs). 4. A second series of experiments was conducted in RS and LB cells. Somatostatin reduced the amplitude ofpharmacologically isolated GABA(A) IPSPs in both cell types. In IB cells but not RS cells there was a correlation between this effect and the somatostatin-induced hyperpolarization. Somatostatin also reduced the amplitude of isolated GABA(B) IPSPs in both cell types, but more soin IB cells. 5. Somatostatin had no effect on the reversal potential of either IPSP in either cell type and no effect on the GABA(A)-mediated conductance in either cell type. In contrast, the GABA(B)-mediated conductance was reduced, especially in IB cells. 6. The effects of somatostatin on GABA(A) IPSPs are principally a result of membrane shunting and reductions in ionic driving force, but these mechanisms do not account for the reduction in GABA(B) IPSPs. 7. We suggest that the combined effects of somatostatin are likely to alter the balance between fast and slow inhibition and to do so more in IB cells than in RS cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:22:59