Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EFFICACY AND SAFETY OF REPEATED HEPATOCYTE TRANSPLANTATION FOR SIGNIFICANT LIVER REPOPULATION IN RODENTS
Autore:
RAJVANSHI P; KERR A; BHARGAVA KK; BURK RD; GUPTA S;
Indirizzi:
ALBERT EINSTEIN COLL MED,LONG ISL JEWISH MED CTR,MARION BESSIN LIVER RES CTR,UILMANN 625 BRONX NY 10461 ALBERT EINSTEIN COLL MED,LONG ISL JEWISH MED CTR,MARION BESSIN LIVER RES CTR BRONX NY 10461 ALBERT EINSTEIN COLL MED,LONG ISL JEWISH MED CTR,DIV GASTROENTEROL,DEPT MED BRONX NY 10461 ALBERT EINSTEIN COLL MED,LONG ISL JEWISH MED CTR,DEPT RADIOL BRONX NY10461 ALBERT EINSTEIN COLL MED,LONG ISL JEWISH MED CTR,DEPT PEDIAT BRONX NY10461 ALBERT EINSTEIN COLL MED,LONG ISL JEWISH MED CTR,DEPT MICROBIOL & IMMUNOL BRONX NY 10461 ALBERT EINSTEIN COLL MED,LONG ISL JEWISH MED CTR,DEPT OBSTET & GYNECOL BRONX NY 10461 ALBERT EINSTEIN COLL MED,LONG ISL JEWISH MED CTR,DEPT NUCL MED BRONX NY 10461
Titolo Testata:
Gastroenterology
fascicolo: 4, volume: 111, anno: 1996,
pagine: 1092 - 1102
SICI:
0016-5085(1996)111:4<1092:EASORH>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXVIVO GENE-THERAPY; RAT-LIVER; FAMILIAL HYPERCHOLESTEROLEMIA; TRANSGENIC MICE; CELLS; DEFICIENT; EXPRESSION; PARENCHYMA; ENZYME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
P. Rajvanshi et al., "EFFICACY AND SAFETY OF REPEATED HEPATOCYTE TRANSPLANTATION FOR SIGNIFICANT LIVER REPOPULATION IN RODENTS", Gastroenterology, 111(4), 1996, pp. 1092-1102

Abstract

Background and Aims: Significant liver repopulation by hepatocyte transplantation will advance clinical applications. The aim of this studywas to test the hypothesis that translocation of transplanted cells into liver plates will allow repeated cell transplantation for increasing the transplanted hepatocyte mass, Methods: Hepatocytes weve transplanted via spleen from either F344 rats into syngeneic recipients deficient in dipeptidyl peptidase IV or from transgenic hepatitis B surfaceantigen-producing G26 mice with hepatitis B virus into nontransgenic congeneic recipients. Portosystemic shunting was shown by radiologicalmethods, Results: Repeated hepatocyte transplantation led to progressively increased liver repopulation, Transplantation of 1.75 x 10(8) hepatocytes in three divided doses repopulated more than an estimated 5%of the host rat liver, with 3.8 x 10(6) +/- 0.1 x 10(6) transplanted cells/cm(3) liver. This was a tenfold or threefold mean increase in transplanted cell number compared with recipients of 2.0 x 10(7) or 7.5 x 10(7) cells transplanted in single sessions, respectively (P < 0.001), Repeated hepatocyte transplantation interfered with neither cell integrations in liver parenchyma nov secretory function of transplanted cells. Portal hypertension, portasystemic collaterals, or intrahepaticshunting were not observed in cell recipients. Conclusions: Repeated transplantation of hepatocytes in large numbers is safe and effective and should advance strategies for liver repopulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 07:55:50