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Titolo:
TACHYKININS MEDIATE VAGAL INHIBITION OF GASTRIN-SECRETION IN PIGS
Autore:
SCHMIDT P; POULSEN SS; HILSTED L; RASMUSSEN TN; HOLST JJ;
Indirizzi:
UNIV COPENHAGEN,PANUM INST,DEPT MED PHYSIOL,BLEGDAMSVEJ 3 DK-2200 COPENHAGEN N DENMARK UNIV COPENHAGEN,PANUM INST,DEPT MED PHYSIOL DK-2200 COPENHAGEN N DENMARK UNIV COPENHAGEN,PANUM INST,DEPT ANAT DK-2200 COPENHAGEN N DENMARK UNIV COPENHAGEN,NATL UNIV HOSP,DEPT CLIN BIOCHEM COPENHAGEN DENMARK UNIV COPENHAGEN,NATL UNIV HOSP,DEPT EXPT PATHOL COPENHAGEN DENMARK
Titolo Testata:
Gastroenterology
fascicolo: 4, volume: 111, anno: 1996,
pagine: 925 - 935
SICI:
0016-5085(1996)111:4<925:TMVIOG>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR ANTAGONIST CP-96,345; POTENT NONPEPTIDE ANTAGONIST; PERFUSED RAT STOMACH; SUBSTANCE-P-LIKE; GASTROINTESTINAL-TRACT; SOMATOSTATIN RELEASE; NEUROKININ-A; GUINEA-PIG; IMMUNOREACTIVITY; PEPTIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
P. Schmidt et al., "TACHYKININS MEDIATE VAGAL INHIBITION OF GASTRIN-SECRETION IN PIGS", Gastroenterology, 111(4), 1996, pp. 925-935

Abstract

Background & Aims: Electrical vagal stimulation activates both stimulatory and inhibitory nerve fibers regulating gastrin release in the porcine antrum, The aim of this study was to examine the role of tachykinins in the inhibitory vagal control of gastrin release in the porcineantrum, Methods: Tachykinin presence was examined by immunohistochemistry and specific radioimmunoassays. Effects of electrical vagus stimulation and capsaicin infusion on tachykinin, gastrin, and somatostatinrelease were studied using the isolated perfused porcine antrum with intact vagal innervation, Effects of substance P and neurokinin A on gastrin and somatostatin secretion were investigated using nonpeptide neurokinin 1 and 2 receptor antagonists and somatostatin immunoneutralization. Results: Porcine antrum contained substance P and neurokinin Aand did not contain neurokinin B, with immunoreactive nerves situatedclose to gastrin- and somatostatin-immunoreactive cells. Vagus stimulation released substance P, neurokinin A, gastrin, and somatostatin, whereas capsaicin stimulated only tachykinin release, Tachykinin infusions increased somatostatin and decreased gastrin secretion, the latterbeing unaffected by somatostatin immunoneutralization and both being blocked by a combination of neurokinin 1 and 2 receptor antagonists, which also increased gastrin output during vagal stimulation, Conclusions: Tachykinins strongly inhibit gastrin and stimulate somatostatin secretion in porcine antrum, and tachykininergic nerves mediate inhibitory vagal regulation of gastrin release.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:58:01