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Titolo:
ANTITUMOR-ACTIVITY OF NATURAL-TYPE HUMAN TUMOR-NECROSIS-FACTOR ON EXPERIMENTAL BRAIN-TUMORS IN RATS
Autore:
NAKAICHI M; TAKEUCHI A; SASAKI N; SHITARA N; TAKAKURA K;
Indirizzi:
YAMAGUCHI UNIV,VET HOSP,DEPT VET SURG YAMAGUCHI 753 JAPAN UNIV TOKYO,DEPT VET SURG TOKYO 113 JAPAN TOKYO METROPOLITAN KOMAGOME HOSP,DEPT VET SURG TOKYO 113 JAPAN TOKYO WOMENS MED COLL,DEPT VET SURG TOKYO 162 JAPAN
Titolo Testata:
Journal of veterinary medical science
fascicolo: 9, volume: 58, anno: 1996,
pagine: 885 - 891
SICI:
0916-7250(1996)58:9<885:AONHTO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADHESION MOLECULE-1 ICAM-1; CENTRAL-NERVOUS-SYSTEM; ENDOTHELIAL-CELLS; CYTO-TOXICITY; FACTOR-ALPHA; PHASE-I; ACTIVATION; PERMEABILITY; NEUTROPHILS; EXPRESSION;
Keywords:
ANTITUMOR ACTIVITY; BRAIN TUMOR; INFLAMMATORY CYTOKINE; RAT; TUMOR NECROSIS FACTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
M. Nakaichi et al., "ANTITUMOR-ACTIVITY OF NATURAL-TYPE HUMAN TUMOR-NECROSIS-FACTOR ON EXPERIMENTAL BRAIN-TUMORS IN RATS", Journal of veterinary medical science, 58(9), 1996, pp. 885-891

Abstract

The effects of intralesional injection of newly synthesized natural-type human tumor necrosis factor (nh-TNF) on experimental brain tumors in rats were investigated. The repeated injection of 5,000 U of nh-TNFinto the tumor resulted in tile prolongation of the survival time of the rats. More than half of the nh-TNF treated tumors were red, and were characterized by histopathological features of marked congestion oftumor vessels. Fibrin formations were also found in the tumor vessels. These histological findings were not observed in the control tumors. Furthermore, coagulative necrosis was observed in the center of some reddish tumors. Leukocytes adhering to vascular endothelium and infiltration of the leukocytes were also observed in the tumors of nh-TNF treated rats. In the immunohistochemical examination, these infiltrated cells were primarily polymorphonuclear leukocytes and macrophages. Expression of intercellular adhesion molecule-1 (ICAM-1) increased on thetumor endothelial cells after the administration of nh-TNF. These results suggest that repeated injection of nh-TNF has a therapeutic effect on brain tumors through its extensive influences on tumor vasculature.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:42:44