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Titolo:
ACTIVATION OF LOCUS-COERULEUS SOMATOSTATIN RECEPTORS INDUCES AN INCREASE OF GROWTH-HORMONE RELEASE IN MALE-RATS
Autore:
MOUNIER F; BLUETPAJOT MT; MOINARD F; KORDON C; EPELBAUM J;
Indirizzi:
INSERM,U159,UNITE RECH DYNAM SYST NEUROENDICRINIENS,2TER RUE ALESIA F-75014 PARIS FRANCE INSERM,U159,UNITE RECH DYNAM SYST NEUROENDICRINIENS F-75014 PARIS FRANCE
Titolo Testata:
Journal of neuroendocrinology
fascicolo: 10, volume: 8, anno: 1996,
pagine: 761 - 764
SICI:
0953-8194(1996)8:10<761:AOLSRI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL NERVOUS-SYSTEM; BINDING-SITES; BRAIN-STEM; ANESTHETIZED RAT; SECRETION; GALANIN; NEURONS; PROJECTIONS; INVOLVEMENT; INJECTION;
Keywords:
GROWTH HORMONE; LOCUS COERULEUS; SOMATOSTATIN; GALANIN; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
F. Mounier et al., "ACTIVATION OF LOCUS-COERULEUS SOMATOSTATIN RECEPTORS INDUCES AN INCREASE OF GROWTH-HORMONE RELEASE IN MALE-RATS", Journal of neuroendocrinology, 8(10), 1996, pp. 761-764

Abstract

Noradrenergic neurons of the locus coeruleus (LC) negatively regulatethe endogenous rhythmicity of growth hormone (GH) secretion, These neurons express high concentrations of receptors for somatostatin (SRIH)and galanin (GAL), two neuropeptides which can affect electrical activity of LC neurons and also centrally modulate plasma GH levels. We thus investigated whether somatostatin and galanin receptors located in the LC are involved in GH regulation, Pulsatile patterns of endogenousGH secretion were monitored after unilateral infusion of the peptidesinto the lateral ventricle (ICV) or into the LC, after lesion of contralateral LC neurons by 6 hydroxydopamine. Neither unilateral LC lesions nor administration of saline affected GH release, When administeredICV, both SRIH (5 mu g/mu l/15 min) and GAL (1 mu g/mu l/15 min) resulted in a marked increase in GH secretion. Infusion of SRIH into the LC induced a significant but weaker stimulation of plasma GH as compared to ICV injections, In contrast, infusion of GAL into the LC was ineffective. These results indicate that somatostatin can exhibit direct effects on noradrenergic neurons of the LC involved in GH regulation, whereas central effects of galanin on the hormone are mediated by distinct structures.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 23:18:04