Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ALTERATION OF G-ALPHA SUBUNITS MESSENGER-RNA LEVELS IN BROMOCRIPTINE RESISTANT PROLACTINOMAS
Autore:
CACCAVELLI L; MORANGERAMOS I; KORDON C; JAQUET P; ENJALBERT A;
Indirizzi:
UNIV LIEGE,LAB BIOL MOL & GENIE GENET,INST CHIMIE,B6 B-4000 LIEGE BELGIUM UNIV AIX MARSEILLE 2,FAC MED NORD,CNRS UMR 9941,ICNE F-13916 MARSEILLE FRANCE CTR PAUL BROCA,INSERM,U159 F-75014 PARIS FRANCE
Titolo Testata:
Journal of neuroendocrinology
fascicolo: 10, volume: 8, anno: 1996,
pagine: 737 - 746
SICI:
0953-8194(1996)8:10<737:AOGSML>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTERIOR-PITUITARY-CELLS; BETA-GAMMA-SUBUNITS; POLYMERASE CHAIN-REACTION; RAT LACTOTROPH CELLS; G-PROTEIN; ADENYLYL CYCLASE; MESSENGER-RNA; DOPAMINE-RECEPTOR; MOLECULAR-CLONING; TUMORS;
Keywords:
G-PROTEIN EXPRESSION; PROLACTINOMAS; BROMOCRIPTINE RESISTANCE; D2 DOPAMINE RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
L. Caccavelli et al., "ALTERATION OF G-ALPHA SUBUNITS MESSENGER-RNA LEVELS IN BROMOCRIPTINE RESISTANT PROLACTINOMAS", Journal of neuroendocrinology, 8(10), 1996, pp. 737-746

Abstract

Patients with prolactinoma are commonly treated with the D2 dopamine agonist bromocriptine, which in most cases, normalizes prolactin (PRL)levels. However, resistance to bromocriptine has been observed in 5 to 18% of tested prolactinomas and is associated to a decrease in both D2 receptor density and mRNA levels, In this study, we used quantitative RT-PCR to investigate whether expression of G alpha proteins could be also modified in bromocriptine resistant prolactinomas, No difference in G alpha o mRNA levels or in the relative expression of G alpha sbetween bromocriptine sensitive and bromocriptine resistant prolactinomas was observed, In contrast, the relative expression of G alpha i(2) was found to be decreased in bromocriptine resistant prolactinomas when compared to that of bromocriptine sensitive prolactinomas, Interestingly, the relative G alpha i(2) expression was correlated to both bromocriptine inhibition of in vitro PRL secretion and D2 receptor mRNA levels, Bromocriptine resistance could thus result from a decrease in D2 dopamine receptors associated with a decrease in G alpha i(2) expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:36:46