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Titolo:
HYPERINSULINEMIA IS ASSOCIATED WITH VENTRICULAR PREMATURE COMPLEXES
Autore:
PAOLISSO G; GUALDIERO P; MANZELLA D; GAMBARDELLA A; VERZA M; GENTILE S; VARRICCHIO M;
Indirizzi:
UNIV NAPLES 2,DEPT GERIATR MED & METAB DIS,SERV ASTANTERIA MED,PIAZZAMIRAGLIA 2 I-80138 NAPLES ITALY
Titolo Testata:
Metabolism, clinical and experimental
fascicolo: 10, volume: 45, anno: 1996,
pagine: 1248 - 1253
SICI:
0026-0495(1996)45:10<1248:HIAWVP>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREE FATTY-ACIDS; INSULIN RESISTANCE; CARDIOVASCULAR-DISEASE; K+ CHANNELS; RAT-HEART; HYPERTENSION; ARRHYTHMIAS; METABOLISM; MYOCYTES; HYPERTROPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
G. Paolisso et al., "HYPERINSULINEMIA IS ASSOCIATED WITH VENTRICULAR PREMATURE COMPLEXES", Metabolism, clinical and experimental, 45(10), 1996, pp. 1248-1253

Abstract

The study investigated a possible association between fasting plasma insulin (FPI) levels and ventricular premature complexes (VPCs). One hundred eighty-six subjects without coronary artery disease (CAD), diabetes, hypertension, and left ventricular hypertrophy were recruited. All subjects underwent 24-hour electrocardiographic monitoring and oralglucose tolerance testing. The subjects were slightly overweight, normotensive, and nondiabetic. Subjects at the third tertile of FPI concentrations were the oldest and heaviest, with prevalent upper-body fat distribution, and had enhanced fasting plasma triglyceride and potassium concentrations, lower fasting plasma high-density lipoprotein (HDL)cholesterol concentration, and a greater number of VPCs versus subjects at the first and second tertiles. Independently of age, sex, body mass index (BMI), and waist to hip ratio (WHR), VPCs were correlated with FPI concentration (r = .19, P < .01). Multiple logistic regression analyses in which the presence or absence of VPCs was the dependent variable demonstrated that FPI concentrations were associated with VPCs independently of age, sex, BMI, WHR, daily physical activity (DPA), left ventricular mass index (LVMI), plasma low-density lipoprotein (LDL)/HDL cholesterol ratio, and triglyceride concentration (odds ratio [OR], 1.2; 95% confidence interval [CI], 1.0 to 1.6). After addition to the model of fasting plasma free fatty acids ([FFA] OR, 0.7; 95% CI, 0.6 to 1.3) or potassium (OR, 0.7; 95% CI, 0.6 to 1.1) concentrations, the association between FPI concentrations and VPCs is no longer significant. In conclusion, FPI concentrations are associated with VPCs in nondiabetic, normotensive, nonischemic subjects. Copyright (C) 1996 by W.B. Saunders Company

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 08:00:24