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Titolo:
HUMAN RENAL-CELL CARCINOMA TISSUE CONTAINS DENDRITIC CELLS
Autore:
THURNHER M; RADMAYR C; RAMONER R; EBNER S; BOCK G; KLOCKER H; ROMANI N; BARTSCH G;
Indirizzi:
INNSBRUCK UNIV,DEPT UROL,ANICHSTR 35 A-6020 INNSBRUCK AUSTRIA INNSBRUCK UNIV,DEPT DERMATOL A-6020 INNSBRUCK AUSTRIA INNSBRUCK UNIV,INST GEN & EXPT PATHOL A-6020 INNSBRUCK AUSTRIA
Titolo Testata:
International journal of cancer
fascicolo: 1, volume: 68, anno: 1996,
pagine: 1 - 7
SICI:
0020-7136(1996)68:1<1:HRCTCD>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; CYTOKINE GENE-EXPRESSION; TUMOR-NECROSIS-FACTOR; B7-2 CD86 EXPRESSION; LANGERHANS CELLS; T-LYMPHOCYTES; BONE-MARROW; HUMAN BLOOD; PROGENITORS; RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
M. Thurnher et al., "HUMAN RENAL-CELL CARCINOMA TISSUE CONTAINS DENDRITIC CELLS", International journal of cancer, 68(1), 1996, pp. 1-7

Abstract

Immune surveillance of cancer requires antigen-presenting cells whichactivate T cells specific for tumor-associated antigens. We show herethat substantial numbers of dendritic cells, which are the most potent antigen-presenting cells, emigrate from renal-tumor explants in organ culture. Tumor-derived dendritic cells presented with all characteristics of mature dendritic cells. Dendritic cells could be identified by typical cytoplasmic projections (=veils). They expressed high levelsof MHC products and of the co-stimulator CD86 (B7-2). Dendritic cellsexpressed the CD45RO isoform but not CD45RA. The most important pointwas that up to 9% of the emigrating leukocytes expressed the CD83 antigen, a specific marker for mature dendritic cells. CD83(+) cells wereapproximately 40-fold enriched in the tumor tissue as compared to theperipheral blood. In contrast to cultured blood dendritic cells, tumor-emigrant dendritic cells had a reduced potential to capture soluble antigen, as shown by the exclusion of fluoresceinated Dextran molecules. Finally, in mixed leukocyte reactions, tumor-derived dendritic cells were able to stimulate naive T cells from cord blood, which is a unique feature of dendritic cells. This study demonstrates that genuine dendritic cells reside in or infiltrate renal-cell carcinoma tissue. The failure of patients with renal-cell carcinoma to mount an anti-tumorimmune response despite the presence of professional antigen-presenting cells in the tumor tissue suggests that tumor-associated dendritic cells are suppressed in situ, in a similar way to that described for tumor-infiltrating lymphocytes. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:02:34