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Titolo:
ANDROGEN REPLACEMENT THERAPY IN WOMEN - MYTHS AND REALITIES
Autore:
CASSON PR; CARSON SA;
Indirizzi:
BAYLOR COLL MED,DIV REPROD ENDOCRINOL & INFERTIL,DEPT OBSTET & GYNECOL,6550 FANNIN,SUITE 801 HOUSTON TX 77030
Titolo Testata:
International journal of fertility and menopausal studies
fascicolo: 4, volume: 41, anno: 1996,
pagine: 412 - 422
SICI:
1069-3130(1996)41:4<412:ARTIW->2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
POST-MENOPAUSAL WOMEN; POSTMENOPAUSAL WOMEN; DEHYDROEPIANDROSTERONE DHEA; TESTOSTERONE IMPLANTS; ORAL DEHYDROEPIANDROSTERONE; SURGICAL MENOPAUSE; SEX-HORMONES; T-CELLS; ESTROGEN; SULFATE;
Keywords:
ANDROGEN; DEHYDROEPIANDROSTERONE; TESTOSTERONE; MENOPAUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
79
Recensione:
Indirizzi per estratti:
Citazione:
P.R. Casson e S.A. Carson, "ANDROGEN REPLACEMENT THERAPY IN WOMEN - MYTHS AND REALITIES", International journal of fertility and menopausal studies, 41(4), 1996, pp. 412-422

Abstract

In recent years, much attention has been directed at the potential ofandrogen replacement in the menopausal woman. Testosterone (T) replacement, in various forms, is widely used. However, evidence is lacking for a profound T deficiency state with natural menopause, Data confirming efficacy are also scant, and side effects have been demonstrated with prolonged therapy. The adrenal androgens, dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S), also in contradistinction to T, decline substantially with age. Preliminary studies involving replacement of physiologic levels of DHEA have demonstrated some potential benefits: enhancement of the immune system and enhancement of the growth hormone axis. However, long-term trials have not been performed to date, so this modality of androgen replacement remains in the realm of clinical investigation. Ovarian and adrenal androgen replacement in menopausal women, while theoretically appealing, remains imperfect to date and should be used judiciously, if at all.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:13:35