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Titolo:
PROTECTIVE EFFECT OF THE SODIUM HYDROGEN EXCHANGE INHIBITORS DURING GLOBAL LOW-FLOW ISCHEMIA/
Autore:
KHANDOUDI N; LAVILLE MP; BRIL A;
Indirizzi:
SMITH KLINE BEECHAM LABS PHARMACEUT,4 RUE CHESNAY BEAUREGARD,BP 58 F-35762 ST GREGOIRE FRANCE SMITH KLINE BEECHAM LABS PHARMACEUT F-35762 ST GREGOIRE FRANCE
Titolo Testata:
Journal of cardiovascular pharmacology
fascicolo: 4, volume: 28, anno: 1996,
pagine: 540 - 546
SICI:
0160-2446(1996)28:4<540:PEOTSH>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NA+-H+ EXCHANGE; SODIUM-HYDROGEN-EXCHANGE; DIABETIC RAT HEARTS; INTRACELLULAR PH; POSTISCHEMIC REPERFUSION; CARDIAC ISCHEMIA; PERFUSED HEART; NA/H EXCHANGE; RECOVERY; AMILORIDE;
Keywords:
ISOLATED WORKING RAT HEART; LOW-FLOW ISCHEMIA; REPERFUSION; NA+/H+ EXCHANGE; 5-(N-ETHYL-N-ISOPROPYL) AMILORIDE; HOE-694;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
N. Khandoudi et al., "PROTECTIVE EFFECT OF THE SODIUM HYDROGEN EXCHANGE INHIBITORS DURING GLOBAL LOW-FLOW ISCHEMIA/", Journal of cardiovascular pharmacology, 28(4), 1996, pp. 540-546

Abstract

We investigated the potential role of the Na+/H+ exchanger (NHE) during global low-flow ischemia. Isolated working rat hearts were subjected to a low-flow ischemic period of 30 or 60 min at 37 degrees C and then reperfused for 30 min. Under those conditions, the effects of two NHE inhibitors 3-methylsulphonyl-4-piperidinobenzoyl guanidine methanesulphonate (HOE-694, 1 mu M) and 5-(N-ethyl-N-isopropyl) amiloride (EIPA, 1 mu M), were compared. When added to the perfusion fluid 15 min before induction of ischemia, EIPA partially preserved aortic output (AO) during either a 30- or 60-min low-flow period. A lesser effect, which was not statistically significant, was observed with HOE-694. Therefore, after 30-min ischemia, AO was 18.7 +/- 2.7, 31.4 +/- 3.3% (p < 0.05 vs. control group) and 25.8 +/- 3.2% of the preischemic value in control and EIPA- and HOE-694-treated groups, respectively. Similarly, after 60-min low-flow ischemia, AO was 15.7 +/- 1.8, 32.7 +/- 4.2% (p <0.05 vs. control group) and 23.3 +/- 5.6% in control and EIPA- and HOE-694-treated groups, respectively. When EIPA and HOE-694 were added to the perfusion solution during the 60-min ischemic period, i.e., at 15 min of low-flow ischemia, AO was maintained at 38.9 +/- 4.9 and 30.2+/- 2.4% (vs. 15.7 +/- 1.8% in the controls) in HOE-694- and EIPA treated groups, respectively. EIPA but not HOE-694 also significantly (p < 0.05) improved the AO recovery during reperfusion. When administeredlater during ischemia, EIPA but not HOE-694 caused some recovery of AO during the remainder of the ischemic period but did not aid recoveryduring reperfusion. Our data suggest that although inhibition of NHE may be of some benefit during low-flow ischemia, additional effects may be necessary to provide a more efficient cardioprotection. An additional action, e.g., inhibition of the Na+/HCO3- cotransporter, could explain the superior effect of EIPA with respect to HOE-694.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 14:59:50