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Titolo:
INTERPHASE-FISH EXAMINATIONS IN PARAFFIN SECTIONS FROM BENIGN, PRECANCEROUS, AND CANCEROUS LESIONS OF THE SKIN AND ORAL-MUCOSA
Autore:
DIMMLER A; KIESEWETTER F; LIEHR T; NEUBAUER S; SCHELL H; GEBHART E;
Indirizzi:
UNIV ERLANGEN NURNBERG,INST HUMAN GENET,TUMOR GENET GRP,SCHWABACHANLAGE 10 D-91054 ERLANGEN GERMANY UNIV ERLANGEN NURNBERG,INST HUMAN GENET,TUMOR GENET GRP D-91054 ERLANGEN GERMANY UNIV ERLANGEN NURNBERG,DERMATOL CLIN D-91054 ERLANGEN GERMANY
Titolo Testata:
International journal of oncology
fascicolo: 1, volume: 10, anno: 1997,
pagine: 83 - 88
SICI:
1019-6439(1997)10:1<83:IEIPSF>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUAMOUS-CELL CARCINOMAS; CHROMOSOME-ABNORMALITIES; CYTOGENETIC ANALYSIS; HEAD; NECK; ABERRATIONS; TUMORS; HYBRIDIZATION;
Keywords:
FISH; ARCHIVAL PARAFFIN SECTIONS; SQUAMOUS CELL CARCINOMA; BOWEN CARCINOMA; KERATOACANTHOMA; ORAL LICHEN PLANUS; PRECANCEROUS LEUKOPLAKIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
A. Dimmler et al., "INTERPHASE-FISH EXAMINATIONS IN PARAFFIN SECTIONS FROM BENIGN, PRECANCEROUS, AND CANCEROUS LESIONS OF THE SKIN AND ORAL-MUCOSA", International journal of oncology, 10(1), 1997, pp. 83-88

Abstract

In a preliminary pilot study centromeric probes for chromosomes #7, #8, #11, and #17 and two-colour-FISH were applied on interphase nuclei of 10 coded histologic thin sections obtained from archival paraffin material from precancerous lesions and malignant tumors of the mouth epithelium. Brilliant signals could be obtained in this material withoutany computerized processing. Among the ten coded probes, localized malignant areas within grade 2 leukoplakias could be detected by their increased number of aneusomic cells, as could the samples from carcinomas. In extension of this study archival paraffin material from 30 epithelial tumors of the skin were examined. The studied squamous cell andBowen carcinomas were characterized by a large number of chromosomally aberrant subclones and gains of chromosomes were the prevailing finding. In contrast, keratoacanthomas showed distinctly less clonal variation, their majority exhibiting small, but significant clones with chromosome loss, particularly of chromosome #7, less distinctly of chromosome #17.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 00:43:22