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Titolo:
THE QUINOLINONE DERIVATIVE VESNARINONE POTENTIATES THE CYTOTOXICITY OF DOXORUBICIN IN HL-60 LEUKEMIA-CELLS
Autore:
YAMAMOTO M; MAEHARA Y; SAKAGUCHI Y; KUSUMOTO T; BABA H; SUGIMACHI K;
Indirizzi:
KYUSHU UNIV,FAC MED,DEPT SURG 2,HIGASHI KU,3-1-1 MAIDASHI FUKUOKA 812JAPAN KYUSHU UNIV,FAC MED,DEPT SURG 2,HIGASHI KU FUKUOKA 812 JAPAN KYUSHU UNIV HOSP,CTR CANC FUKUOKA 812 JAPAN NATL CANC CTR,DEPT SURG GASTROENTEROL FUKUOKA JAPAN
Titolo Testata:
International journal of oncology
fascicolo: 1, volume: 10, anno: 1997,
pagine: 53 - 57
SICI:
1019-6439(1997)10:1<53:TQDVPT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITIVE INOTROPIC DRUG; ANTICANCER AGENTS; APOPTOSIS; ADRIAMYCIN; OPC-8212; DEATH; CYCLE; DIPYRIDAMOLE; RESISTANCE; MEMBRANE;
Keywords:
VESNARINONE; APOPTOSIS; COMBINED EFFECT; DOXORUBICIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
M. Yamamoto et al., "THE QUINOLINONE DERIVATIVE VESNARINONE POTENTIATES THE CYTOTOXICITY OF DOXORUBICIN IN HL-60 LEUKEMIA-CELLS", International journal of oncology, 10(1), 1997, pp. 53-57

Abstract

Vesnarinone, (3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1- piperazinyl]-2(1H)-quinolinone), a quinolinone derivative, is a positive inotropicagent. We examined the cytotoxicity either by vesnarinone alone or incombination with doxorubicin (DXR), in vitro. The cytotoxic effect ofvesnarinone against HL-60 cells did not increase, even at concentrations as high as (50 mu g/ml). The cytotoxicity of DXR, however, was enhanced after being combined with 30 mu g/ml of vesnarinone. The intracellular level of DXR increased when DXR was administered after incubation with vesnarinone and the efflux of DXR was delayed when the cells were incubated in the presence of vesnarinone after DXR exposure. Flow cytometry showed that the combination of DXR and vesnarinone increasedthe cell population below the G(0)/G(1) region. Vesnarinone induced DNA ladder formation, but only when these cells were incubated for 72 h, while in addition, when DXR was combined with vesnarinone, the DNA ladder formation was enhanced. Based on the above findings, we thus conclude that the cytotoxicity of DXR was enhanced when combined with vesnarinone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 01:38:01