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Titolo:
DOPAMINE D2 RECEPTOR-BINDING IS REDUCED IN WILSONS-DISEASE - CORRELATION OF NEUROLOGICAL DEFICITS WITH STRIATAL I-123 IODOBENZAMIDE BINDING
Autore:
ODER W; BRUCKE T; KOLLEGGER H; SPATT J; ASENBAUM S; DEECKE L;
Indirizzi:
UNIV VIENNA,NEUROL CLIN,WAHRINGER GURTEL 18-20 A-1090 VIENNA AUSTRIA UNIV VIENNA,NEUROL CLIN A-1090 VIENNA AUSTRIA
Titolo Testata:
Journal of neural transmission
fascicolo: 8-9, volume: 103, anno: 1996,
pagine: 1093 - 1103
SICI:
0300-9564(1996)103:8-9<1093:DDRIRI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; BRAIN; MRI;
Keywords:
WILSONS DISEASE; NEUROLOGICAL IMPAIRMENT; DOPAMINE; D2 RECEPTOR; IBZM-SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
W. Oder et al., "DOPAMINE D2 RECEPTOR-BINDING IS REDUCED IN WILSONS-DISEASE - CORRELATION OF NEUROLOGICAL DEFICITS WITH STRIATAL I-123 IODOBENZAMIDE BINDING", Journal of neural transmission, 103(8-9), 1996, pp. 1093-1103

Abstract

To visualise and quantify dopamine D2 receptor binding in the corpus striatum of patients with neurological Wilson's disease (WD) I-123-Iodobenzamide (IBZM) binding was measured using single photon emission computer tomography (SPECT). Ratios of striatal to frontal countrates were calculated in 8 patients and in 21 healthy control subjects. We found reduced IBZM binding ratios in all patients with WD in comparison to those in controls (1.48 +/- 0.13 vs. 1.73 +/- 0.09). The reduction in IBZM binding was correlated with the overall severity of neurological deficits and the severity of dysarthria (correlation coefficients -0.86 [p < 0.01] and -0.79 [p < 0.01], respectively). When patients of three different subgroups of neurological WD were compared no differences in IBZM binding were found. We conclude that assessing basal ganglia function in vivo using IBZM-SPECT is a valuable diagnostic tool in WD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 22:42:26