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Titolo:
LACK OF EFFECT OF REPEATED ADMINISTRATION OF MILNACIPRAN, A DOUBLE NORADRENALINE AND SEROTONIN REUPTAKE INHIBITOR, ON THE BETA-ADRENOCEPTOR-LINKED ADENYLATE-CYCLASE SYSTEM IN THE RAT CEREBRAL-CORTEX
Autore:
NELIAT G; BODINIER MC; PANCONI E; BRILEY M;
Indirizzi:
CTR RECH PIERRE FABRE,17 AVE JEAN MOULIN F-81100 CASTRES FRANCE CTR RECH PIERRE FABRE F-81100 CASTRES FRANCE CEREP F-86600 CELLE LEVESCAULT FRANCE CTR DEV PIERRE FABRE F-92654 BOULOGNE FRANCE
Titolo Testata:
Neuropharmacology
fascicolo: 5, volume: 35, anno: 1996,
pagine: 589 - 593
SICI:
0028-3908(1996)35:5<589:LOEORA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADRENERGIC-RECEPTOR BINDING; DOWN-REGULATION; ANTIDEPRESSANT; BRAIN; DRUG; HYDROCHLORIDE; RECOGNITION; MIDALCIPRAN; SENSITIVITY; IMIPRAMINE;
Keywords:
MILNACIPRAN; IMIPRAMINE; BETA-ADRENOCEPTOR BINDING; BETA-ADRENOCEPTOR-LINKED ADENYLATE CYCLASE; ANTIDEPRESSANTS; ADENYLATE CYCLASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
G. Neliat et al., "LACK OF EFFECT OF REPEATED ADMINISTRATION OF MILNACIPRAN, A DOUBLE NORADRENALINE AND SEROTONIN REUPTAKE INHIBITOR, ON THE BETA-ADRENOCEPTOR-LINKED ADENYLATE-CYCLASE SYSTEM IN THE RAT CEREBRAL-CORTEX", Neuropharmacology, 35(5), 1996, pp. 589-593

Abstract

The effects of subacute administration of the double noradrenaline and serotonin uptake inhibitor antidepressant, milnacipran, and the tricyclic antidepressant, imipramine, on radioligand binding to beta-adrenergic receptors and on beta-adrenergic agonist-stimulated adenylate cyclase activity, in the rat cerebral cortex, have been determined. Ratswere injected intraperitoneally for 21 days with milnacipran (3, 10 or 30 mg/kg/day) or imipramine (10 mg/kg/day). The treatment with milnacipran up to 30 mg/kg/day did not modify either the maximum number of [H-3]CGP-12177 binding sites (B-max) or the equilibrium dissociation constant (K-d) On the other hand, treatment of the rats with 10 mg/kg/day imipramine induced a decrease (27%) in B-max [H-3]CGP-12177 bindingsites without affecting the K-d value. Furthermore, milnacipran did not affect the stimulation of cAMP production induced by either 30 mu Misoprenaline, 10 mu M GTP gamma S or 10 mu M forskolin. Under similarconditions, treatment with imipramine reduced by 70% the isoprenaline-induced stimulation of cAMP production without affecting that inducedby either GTP gamma S or forskolin. These results demonstrate that, unlike imipramine, subacute administration of milnacipran does not produce any change in beta-adrenoceptor sensitivity in the rat brain cortex. Copyright (C) 1996 Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 14:20:51