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Titolo:
THE ROLE OF 5-HT1A AUTORECEPTORS AND ALPHA(1)-ADRENOCEPTORS IN THE INHIBITION OF 5-HT RELEASE .2. NAN-190 AND SDZ-216-525
Autore:
SHARP T; UMBERS V; HJORTH S;
Indirizzi:
UNIV OXFORD,RADCLIFFE INFIRM,DEPT CLIN PHARMACOL,WOODSTOCK RD OXFORD OX2 6HE ENGLAND GOTHENBURG UNIV,DEPT PHARMACOL S-41390 GOTHENBURG SWEDEN
Titolo Testata:
Neuropharmacology
fascicolo: 6, volume: 35, anno: 1996,
pagine: 735 - 741
SICI:
0028-3908(1996)35:6<735:TRO5AA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR ANTAGONIST NAN-190; BRAIN MICRODIALYSIS; IN-VIVO; 5-HYDROXYTRYPTAMINE RELEASE; DORSAL RAPHE; RAT; INVIVO; WAY100135; AGONISTS; SEROTONIN(1A);
Keywords:
MICRODIALYSIS; 5-HT1A RECEPTOR; ALPHA(1)-ADRENOCEPTOR; NAN-190; SDZ 216-525; WAY 100135; WAY 100635;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
T. Sharp et al., "THE ROLE OF 5-HT1A AUTORECEPTORS AND ALPHA(1)-ADRENOCEPTORS IN THE INHIBITION OF 5-HT RELEASE .2. NAN-190 AND SDZ-216-525", Neuropharmacology, 35(6), 1996, pp. 735-741

Abstract

Novel 5-HT1A receptor antagonists, WAY 100135 and WAY 100635, were used to test the involvement of 5-HT1A receptors in the decrease of hippocampal extracellular 5-HT induced by the 5-HT1A/alpha 1 ligands, NAN-190 and SDZ 216-525. Using microdialysis in anaesthetised rats, it wasfound that WAY 100135 (3 mg/kg s.c.) and WAY 100635 (0.3 mg/kg s.c.) antagonised the decrease of 5-HT induced by the 5-HT1A receptor agonist 8-OH-DPAT (0.025 mg/kg s.c.) but did not alter 5-HT when administered alone;Both NAN-190 (0.03 and 0.3 mg/kg s.c.) and SDZ 216-525 (1 mg/kg s.c.) decreased 5-HT. The effect of 0.03 mg/kg s.c. NAN-190 was antagonised by WAY 100135 (3 mg/kg s.c.) and WAY 100635 (0.3 mg/kg s.c.). The effect of SDZ 216-525 (1 mg/kg s.c.) was also blocked by WAY 100635 (0.3 mg/kg s.c.). However, the 5-HT response to a high-dose of NAN-190 (0.3 mg/kg s.c.) was not antagonised by WAY 100635 (0.3 or 3 mg/kg s.c.). Our experiments using WAY 100635 and WAY 100135 provide clear evidence that NAN-190 and SDZ 216-525 act as agonists at the 5-HT1A autoreceptor, supporting our earlier studies using the non-selective 5-HT1A antagonist, pindolol. However, our data reveal that, at least in the case of NAN-190, non-5-HT1A receptor mechanisms mediate the decreaseof 5-HT induced by higher doses. A lack of specifity of NAN-190 (and possibly SDZ 216-525) at high doses may explain the failure of previous studies to detect a 5-HT1A receptor agonist action. Copyright (C) 1996 Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 13:50:00