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Titolo:
PREVALENCE OF HYPOPIGMENTED MACULES IN A HEALTHY POPULATION
Autore:
VANDERHOOFT SL; FRANCIS JS; PAGON RA; SMITH LT; SYBERT VP;
Indirizzi:
UNIV UTAH,HLTH SCI CTR,DEPT DERMATOL,50 N MED DR SALT LAKE CITY UT 84132 UNIV WASHINGTON,SCH MED,DEPT MED DERMATOL SEATTLE WA 98195 UNIV WASHINGTON,SCH MED,DEPT PEDIAT DERMATOL & MED GENET SEATTLE WA 98195 UNIV WASHINGTON,SCH MED,DEPT OPHTHALMOL SEATTLE WA 98195 UNIV WASHINGTON,SCH MED,DEPT BIOL STRUCT SEATTLE WA 98195 CHILDRENS HOSP SEATTLE WA 00000 UNIV WASHINGTON,MED CTR SEATTLE WA 98195
Titolo Testata:
The Journal of pediatrics
fascicolo: 3, volume: 129, anno: 1996,
pagine: 355 - 361
SICI:
0022-3476(1996)129:3<355:POHMIA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUBEROUS SCLEROSIS; GENETIC-HETEROGENEITY; NEWBORN-INFANTS; HYPOMELANOSIS; CHROMOSOME-9; LESIONS; LOCUS; SPOTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
S.L. Vanderhooft et al., "PREVALENCE OF HYPOPIGMENTED MACULES IN A HEALTHY POPULATION", The Journal of pediatrics, 129(3), 1996, pp. 355-361

Abstract

Objective: Although hypopigmented macules are an important manifestation of tuberous sclerosis (TS), the probability of TS in healthy individuals who have hypopigmented macules is unknown. The purpose of this study was to establish the prevalence of hypopigmented macules among across section of the general white population. Study design: The skinof 423 white individuals younger than 45 years of age was screened for hypopigmented macules with ambient incandescent and fluorescent light and a Wood lamp. Indirect ophthalmoscopy was performed in patients with unexplained hypopigmentation to screen for retinal manifestations of TS. Results: Twenty individuals (4.7%) had at least one hypopigmented macule. Of these, four had more than one macule. None had more thanthree. Two (8%) of the 25 hypopigmented macules were identified only with a Wood lamp. Indirect ophthalmoscopy was performed in 13 (65%) ofthese 20 individuals. None showed the retinal findings of TS. Conclusions: The prevalence of hypopigmented macules in the general population has been underestimated. The presence of a few hypopigmented maculeson the skin of an otherwise healthy individual without a family history of TS need not prompt an evaluation to rule out this disorder.

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Documento generato il 03/12/20 alle ore 05:48:50