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Titolo:
CHRONIC MORPHINE INDUCES VISIBLE CHANGES IN THE MORPHOLOGY OF MESOLIMBIC DOPAMINE NEURONS
Autore:
SKLAIRTAVRON L; SHI WX; LANE SB; HARRIS HW; BUNNEY BS; NESTLER EJ;
Indirizzi:
YALE UNIV,SCH MED,DEPT PSYCHIAT,LAB MOL PSYCHIAT,34 PK ST NEW HAVEN CT 06508 YALE UNIV,SCH MED,DEPT PSYCHIAT,LAB MOL PSYCHIAT NEW HAVEN CT 06508 YALE UNIV,SCH MED,DEPT PHARMACOL,LAB MOL PSYCHIAT NEW HAVEN CT 06508 CONNECTICUT MENTAL HLTH CTR NEW HAVEN CT 06508
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 20, volume: 93, anno: 1996,
pagine: 11202 - 11207
SICI:
0027-8424(1996)93:20<11202:CMIVCI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; METHYL-D-ASPARTATE; NEUROTROPHIC FACTOR; TYROSINE-HYDROXYLASE; DENDRITIC SPINES; NUCLEUS-ACCUMBENS; GABAERGIC NEURONS; CHRONIC COCAINE; DRUG-ADDICTION; RAT;
Keywords:
OPIATE ADDICTION; BRAIN-DERIVED NEUROTROPHIC FACTOR; TYROSINE HYDROXYLASE; LUCIFER YELLOW; MESOLIMBIC DOPAMINE SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
L. Sklairtavron et al., "CHRONIC MORPHINE INDUCES VISIBLE CHANGES IN THE MORPHOLOGY OF MESOLIMBIC DOPAMINE NEURONS", Proceedings of the National Academy of Sciences of the United Statesof America, 93(20), 1996, pp. 11202-11207

Abstract

The mesolimbic dopamine system, which arises in the ventral tegmentalarea (VTA), is an important neural substrate for opiate reinforcementand addiction, Chronic exposure to opiates is known to produce biochemical adaptations in this brain region, We now show that these adaptations are associated with structural changes in VTA dopamine neurons, Individual VTA neurons in paraformaldehyde-fixed brain sections from control or morphine-treated rats were injected with the fluorescent dye Lucifer yellow, The identity of the injected cells as dopaminergic or nondopaminergic was determined by immunohistochemical labeling of the sections for tyrosine hydroxylase, Chronic morphine treatment resultedin a mean approximate to 25% reduction in the area and perimeter of VTA dopamine neurons, This reduction in cell size was prevented by concomitant treatment of rats with naltrexone, an opioid receptor antagonist, as well as by intra-VTA infusion of brain-derived neurotrophic factor, In contrast, chronic morphine treatment did not alter the size ofnondopaminergic neurons in the VTA, nor did it affect the total number of dopaminergic neurons in this brain region, The results of these studies provide direct evidence for structural alterations in VTA dopamine neurons as a consequence of chronic opiate exposure, which could contribute to changes in mesolimbic dopamine function associated with addiction.

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Documento generato il 08/04/20 alle ore 12:04:48