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Titolo:
DIRECT VASOMOTOR EFFECTS OF ISOFLURANE IN SUBEPICARDIAL RESISTANCE VESSELS FROM COLLATERAL-DEPENDENT AND NORMAL CORONARY CIRCULATION OF PIGS
Autore:
PARK KW; LOWENSTEIN E; DAI HB; LOPEZ JJ; STAMLER A; SIMONS M; SELLKE FW;
Indirizzi:
HARVARD UNIV,DEPT SURG,DIV CARDIOTHORAC SURG,BETH ISRAEL HOSP,SCH MED,DANA 905,330 BROOKLINE AVE BOSTON MA 02215 HARVARD UNIV,DEPT SURG,DIV CARDIOTHORAC SURG,BETH ISRAEL HOSP,SCH MEDBOSTON MA 02215 HARVARD UNIV,BETH ISRAEL HOSP,SCH MED,DEPT ANESTHESIA & CRIT CARE BOSTON MA 00000 HARVARD UNIV,BETH ISRAEL HOSP,SCH MED,DEPT MED BOSTON MA 00000
Titolo Testata:
Anesthesiology
fascicolo: 3, volume: 85, anno: 1996,
pagine: 584 - 591
SICI:
0003-3022(1996)85:3<584:DVEOII>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL BLOOD-FLOW; CANINE MODEL; ENDOTHELIAL MODULATION; ARTERY DISEASE; HALOTHANE; DOGS; MICROCIRCULATION; REDISTRIBUTION; OCCLUSION; DYSFUNCTION;
Keywords:
ANESTHETICS, VOLATILE, ISOFLURANE; CORONARY CIRCULATION, COLLATERAL-DEPENDENT CIRCULATION, FLOW DISTRIBUTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
K.W. Park et al., "DIRECT VASOMOTOR EFFECTS OF ISOFLURANE IN SUBEPICARDIAL RESISTANCE VESSELS FROM COLLATERAL-DEPENDENT AND NORMAL CORONARY CIRCULATION OF PIGS", Anesthesiology, 85(3), 1996, pp. 584-591

Abstract

Background: The purpose of the current investigation was to determineand compare the direct effect of isoflurane on normal resistance coronary arteries and similarly sized coronary arteries in collateral-dependent (CD) circulation. A differential vasomotor effect of isoflurane might contribute to flow redistribution, either adverse or favorable, between normal and CD regions. Methods: The authors used a swine modelof chronic coronary occlusion. Six weeks after ameroid occluder placement around the left circumflex artery, the heart was removed. Myocardial blood how, measured in vivo before the removal, was lower during rapid atrial pacing in the CD region than in the normally perfused region. These in vivo studies established the existence and location of CDcirculation. Subepicardial microvessels, measuring approximately 100 mu m, were dissected from both the CD region and the normal region. Either with or without preconstriction of the vessels with the thromboxane analogue U46619 1 mu M, direct vasomotor effect of isoflurane was examined in vitro by video microscopy. In addition, vasomotor responsesto endothelin-1, the endothelium-dependent dilator adenosine 5' diphosphate, and the endothelium-independent dilator sodium nitroprusside were compared between CD and normal resistance vessels. Results: Isoflurane caused greater concentration-dependent constriction of the normalvessels than of the CD vessels (P < 0.05); this constrictive effect was masked by preconstriction of the vessels. Vasodilation to ADP was less in CD vessels than in normal vessels (P < 0.001), but vasodilationto sodium nitroprusside was not significantly different (P = 0.45). Vasoconstriction to endothelin-1 was greater in CD vessels than in normal vessels (P < 0.01). Conclusions: The vasoconstrictive effect of isoflurane normally observed in coronary resistance vessels is impaired in resistance vessels that supply a CD area. The basis of this may be related to endothelial dysfunction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:06:01