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Titolo:
ROLE OF CENTRAL-MU, DELTA-1, AND KAPPA-1 OPIOID RECEPTORS IN OPIOID-INDUCED MUSCLE RIGIDITY IN THE RAT
Autore:
VANKOVA ME; WEINGER MB; CHEN DY; BRONSON JB; MOTIS V; KOOB GF;
Indirizzi:
VET AFFAIRS MED CTR 125,3350 LA JOLLA VILLAGE DR SAN DIEGO CA 92161 UNIV CALIF SAN DIEGO,SCH MED,DEPT ANESTHESIOL SAN DIEGO CA 92103 VET AFFAIRS MED CTR,ANESTHESIA RES SERV SAN DIEGO CA 92161 SCRIPPS CLIN & RES FDN,DEPT NEUROPHARMACOL LA JOLLA CA 92037
Titolo Testata:
Anesthesiology
fascicolo: 3, volume: 85, anno: 1996,
pagine: 574 - 583
SICI:
0003-3022(1996)85:3<574:ROCDAK>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED MUSCULAR RIGIDITY; TAIL-FLICK TEST; NOR-BINALTORPHIMINE; MESSENGER-RNA; DIFFERENTIAL ANTAGONISM; AGONISTS; SUBTYPES; MORPHINE; INVOLVEMENT; BINDING;
Keywords:
ANESTHETICS, INTRAVENOUS, ALFENTANIL; COMPLICATIONS, MUSCLE RIGIDITY; ANALGESICS, OPIOID, RECEPTORS; ANTAGONISTS, NARCOTIC; BRAIN, DRUG INJECTIONS; MEASUREMENT TECHNIQUES, ELECTROMYOGRAPHY; ANIMALS, RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
M.E. Vankova et al., "ROLE OF CENTRAL-MU, DELTA-1, AND KAPPA-1 OPIOID RECEPTORS IN OPIOID-INDUCED MUSCLE RIGIDITY IN THE RAT", Anesthesiology, 85(3), 1996, pp. 574-583

Abstract

Background: Opioids appear to produce their physiologic effects by binding to at least three types of opioid receptors, the mu (mu), delta (delta), and kappa (kappa) receptors, Muscle rigidity occurs after administration of supra-analgesic doses of potent mu-preferring agonists like alfentanil. The role of different supraspinal opioid receptors inthis rigidity has been addressed only recently, To elucidate the contribution of central mu, delta, and kappa receptors to muscle rigidity,the effects of intracerebroventricularly administered opioid receptor-selective agonists and antagonists on alfentanil-induced muscle rigidity were examined in rats, Methods: Rats in which chronic intracerebroventricular cannulae had been implanted received an intracerebroventricular infusion of either saline or a mu (D-Ala(2),N-Me-Phe(4)-Gly(5)-olenkephalin; DAMGO), delta(1) (D-Pen(2),D-Pen(5)-enkephalin; DPDFE), or kappa(1) -(2-(1-pyrrolidinyl)-cyclohexyl)-benzene-acetamide methane sulfonate; U50,488H) opioid agonist, Ten minutes later, they received either saline or the mu-agonist alfentanil subcutaneously, Muscle rigidity was assessed using hindlimb electromyographic activity. Differentgroups of animals were pretreated with an intracerebroventricular infusion of either saline or a mu (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2; CTAP), delta (naltrindole), or kappa(1) (norbinaltorphimine) opioidantagonist before administration of either saline or a selective intracerebroventricular agonist, Results: The mu agonist DAMGO alone dose-dependently induced muscle rigidity, This effect was antagonized by pretreat ment with the mu-selective antagonist CTAP. Neither DPDPE nor U50,488H, when administered alone, affected muscle tone, However, both the delta(1) and kappa(1) agonists dose-dependently attenuated alfentanil-induced rigidity, This antagonism of alfentanil rigidity was abolished after pretreatment with the delta (naltrindole) and kappa(1) (nor-binaltorphimine) antagonists, respectively, Conclusions: The present data demonstrate that whereas systemic opiate-induced muscle rigidity is primarily due to the activation of central CI receptors, supraspinal delta(1) and kappa(1) receptors may attenuate this effect, This finding is consistent with previous demonstrations of functional interactions between different central opioid receptor populations in other opiate effects, and could have important pharmacotherapeutic implications.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:02:37