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Titolo:
ETHNIC DIFFERENCES IN CAROTID WALL THICKNESS - THE INSULIN-RESISTANCEATHEROSCLEROSIS STUDY
Autore:
DAGOSTINO RB; BURKE G; OLEARY D; REWERS M; SELBY J; SAVAGE PJ; SAAD MF; BERGMAN RN; HOWARD G; WAGENKNECHT L; HAFFNER SM;
Indirizzi:
BOWMAN GRAY SCH MED,DEPT PUBL HLTH SCI,MED CTR BLVD WINSTON SALEM NC 27157 TUFTS UNIV NEW ENGLAND MED CTR,DEPT RADIOL BOSTON MA 02111 UNIV COLORADO,SCH MED,DEPT PREVENT MED BIOMETR DENVER CO 00000 KAISER PERMANENTE,DIV RES OAKLAND CA 00000 NHLBI,DIV EPIDEMIOL & CLIN APPLICAT,NIH BETHESDA MD 20892 UNIV SO CALIF,SCH MED,DEPT MED LOS ANGELES CA 90033 UNIV SO CALIF,SCH MED,DEPT PHYSIOL & BIOPHYS LOS ANGELES CA 90033 UNIV TEXAS,HLTH SCI CTR,DEPT MED SAN ANTONIO TX 78284
Titolo Testata:
Stroke
fascicolo: 10, volume: 27, anno: 1996,
pagine: 1744 - 1749
SICI:
0039-2499(1996)27:10<1744:EDICWT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; CARDIOVASCULAR RISK-FACTORS; NON-HISPANIC WHITES; BIETHNIC COLORADO POPULATION; IMPAIRED GLUCOSE-TOLERANCE; ISCHEMIC HEART-DISEASE; INTIMA-MEDIA THICKNESS; MIDDLE-AGED ADULTS; B-MODE ULTRASOUND; MEXICAN-AMERICANS;
Keywords:
ATHEROSCLEROSIS; BLACKS; ETHNIC GROUPS; HISPANIC AMERICANS; INSULIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
R.B. Dagostino et al., "ETHNIC DIFFERENCES IN CAROTID WALL THICKNESS - THE INSULIN-RESISTANCEATHEROSCLEROSIS STUDY", Stroke, 27(10), 1996, pp. 1744-1749

Abstract

Background and Purpose Ethnic differences in cardiovascular disease (CVD) morbidity and mortality have been observed in US adults. However,little data exist on differences in indices of preclinical atherosclerosis such as carotid wall intima-media thickness (IMT) for US non-Hispanic whites, Hispanics, and blacks. This study was undertaken to determine whether there were ethnic differences in carotid wall IMT. Methods Internal carotid artery (ICA) IMT and common carotid artery (CCA) IMT, indices of atherosclerosis, were assessed with the use of B-mode ultrasound in 1020 nondiabetic participants in the Insulin Resistance Atherosclerosis Study, a multicenter study designed to examine the association between insulin resistance and carotid atherosclerosis. The study included 281 blacks, 329 Hispanics, and 410 non-Hispanic whites aged 40 to 69 years. Results Blacks had significantly greater CCA IMT than non-Hispanic whites (865 versus 808 mu m); this remained significant after adjustment for major CVD risk factors and insulin sensitivity (864 versus 823 mu m). There were no significant differences in ICA IMT between blacks and non-Hispanic whites. Hispanics had significantly lesser CCA IMT than non-Hispanic whites (749 versus 776 mu m), and these differences remained significant after adjustment for traditional cardiovascular risk factors and insulin sensitivity (750 versus 778 mu m). There were no significant differences in ICA IMT between non-Hispanic whites and Hispanics. Conclusions We conclude that ethnic differences exist in CCA but not in ICA IMT in nondiabetic subjects. These differences in IMT, which are indicators of atherosclerosis, are a noninvasive measure that is consistent with some of the data on clinical endpoints. These differences may be associated with the observed differences in CVD morbidity and mortality among major ethnic groups in the United States.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:34:44