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Titolo:
RETROCONVERSION AND METABOLISM OF [C-13]22 6N-3 IN HUMANS AND RATS AFTER INTAKE OF A SINGLE-DOSE OF [C-13]22/6N-3-TRIACYLGLYCEROLS/
Autore:
BROSSARD N; CROSET M; PACHIAUDI C; RIOU JP; TAYOT JL; LAGARDE M;
Indirizzi:
INST NATL SCI APPL,INSERM,U352,BLDG 406,20 AVE A EINSTEIN F-69621 VILLEURBANNE FRANCE INST NATL SCI APPL,INSERM,U352 F-69621 VILLEURBANNE FRANCE FAC MED R LAENNEC,INSERM,U197 LYON FRANCE IMEDEX,ZI LES TROQUES CHAPONOST FRANCE
Titolo Testata:
The American journal of clinical nutrition
fascicolo: 4, volume: 64, anno: 1996,
pagine: 577 - 586
SICI:
0002-9165(1996)64:4<577:RAMO[6>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
LECITHIN-CHOLESTEROL ACYLTRANSFERASE; N-3 FATTY-ACIDS; 1ST YEAR GROWTH; DOCOSAHEXAENOIC ACID; EICOSAPENTAENOIC ACID; HUMAN PLASMA; FISH OIL; POSITIONAL SPECIFICITY; MASS-SPECTROMETRY; PRETERM INFANTS;
Keywords:
DOCOSAHEXAENOIC ACID; EICOSAPENTAENOIC ACID; RETROCONVERSION; N-3 POLYUNSATURATED FATTY ACIDS; LECITHIN-CHOLESTEROL ACYLTRANSFERASE; STABLE ISOTOPE AND GAS-CHROMATOGRAPHY COMBUSTION ISOTOPE RATIO MASSSPECTROMETRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
N. Brossard et al., "RETROCONVERSION AND METABOLISM OF [C-13]22 6N-3 IN HUMANS AND RATS AFTER INTAKE OF A SINGLE-DOSE OF [C-13]22/6N-3-TRIACYLGLYCEROLS/", The American journal of clinical nutrition, 64(4), 1996, pp. 577-586

Abstract

The apparent retroconversion of docosahexaenoic acid (22:6n-3) to eicosapentaenoic acid (20:5n-3) and docosapentaenoic acid (22:5n-3) was studied in vivo, in rats and humans, after they ingested a single dose of triacylglycerols containing [C-13]22:6n-3 ([C-13]22:6-triacylglycerol), without 22:6n-3 dietary supplementation. The amount of apparent retroconversion and the distribution of the three n-3 polyunsaturated fatty acids (PUFAs) in plasma lipid classes were followed as a functionof time by measuring the appearance of C-13 in these PUFAs with gas-chromatography combustion-isotope ratio mass spectrometry. This [C-13]22:6n-3 retroconversion, calculated by summing the amounts of [C-13]22:5n-3 and [C-13]20:5n-3 in plasma lipids, was lower in humans than in rats, maximum of approximate to 9% of the total plasma [C-13]22:6n-3 inrats, but only 1.4% in humans. The incorporation of [C-13]22:6n-3 and[C-13]22:5n-3 in lipid classes followed their endogenous distributionwith a maximal accumulation in phospholipids, but a low incorporationinto cholesterol esters (CEs), whereas [C-13]20:5n-3 was equally present in phospholipids and CEs. The ratio of the amount of HDL-CE to HDL-phosphatidylcholine for [C-13]20:5n-3 was higher than for [C-13]22:6n-3, indicating a selectivity of the lecithin-cholesterol acyltransferase enzyme with regard to these PUFAs, which may be related to the differences in their biological properties after fish oil feeding. The occurrence of a weak basal 22:6n-3 retroconversion in humans supports feeding this pure PUFA in cases in which 20:5n-3 presents undesirable side effects and when specific alterations of blood lipids are expected.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/08/20 alle ore 19:40:12