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Titolo:
CONTRACTION KINETICS AND MYOSIN ISOFORM COMPOSITION IN SMOOTH-MUSCLE FROM HYPERTROPHIED RAT URINARY-BLADDER
Autore:
SJUVE R; HAASE H; MORANO I; UVELIUS B; ARNER A;
Indirizzi:
LUND UNIV,DEPT PHYSIOL & NEUROSCI,SOLVEGATAN 19 S-22362 LUND SWEDEN LUND UNIV,DEPT PHYSIOL & NEUROSCI S-22362 LUND SWEDEN LUND UNIV,DEPT UROL S-22362 LUND SWEDEN MAX DELBRUCK CTR MOL MED BERLIN GERMANY
Titolo Testata:
Journal of cellular biochemistry
fascicolo: 1, volume: 63, anno: 1996,
pagine: 86 - 93
SICI:
0730-2312(1996)63:1<86:CKAMIC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFRAVESICAL OUTFLOW OBSTRUCTION; PIG TAENIA-COLI; HEAVY-CHAIN; LIGHT CHAIN; GUINEA-PIG; SHORTENING VELOCITY; ACTIN; IDENTIFICATION; PROTEINS; DETRUSOR;
Keywords:
SMOOTH MUSCLE; URINARY BLADDER; HYPERTROPHY; MYOSIN LIGHT CHAIN; MYOSIN HEAVY CHAIN; FORCE-VELOCITY RELATIONSHIP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
R. Sjuve et al., "CONTRACTION KINETICS AND MYOSIN ISOFORM COMPOSITION IN SMOOTH-MUSCLE FROM HYPERTROPHIED RAT URINARY-BLADDER", Journal of cellular biochemistry, 63(1), 1996, pp. 86-93

Abstract

Mechanical properties and isoform composition of myosin heavy and light chains were studied in hypertrophying rat urinary bladders. Growth of the bladder was induced by partial ligation of the urethra. Preparations were obtained after 10 days. In maximally activated skinned preparations from the hypertrophying tissue, the maximal shortening velocity and the rate of force development following photolytic release of ATP were reduced by about 20 and 25%, respectively. Stiffness was unchanged. The relative content of the basic isoform of the essential 17 kDa myosin light chain was doubled in the hypertrophied tissue. The expression of myosin heavy chain with a 7 amino acid insert at the 25K/50Kregion was determined using a peptide-derived antibody against the insert sequence. The relative amount of heavy chain with insert was decreased to 50% in the hypertrophic tissue. The kinetics of the cross-bridge rum-over in the newly formed myosin in the hypertrophic smooth muscle is reduced, which might be related to altered expression of myosinheavy or light chain isoforms. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 02:25:48