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Titolo:
CO2-INDUCED C-FOS EXPRESSION IN THE CNS CATECHOLAMINERGIC NEURONS
Autore:
HAXHIU MA; YUNG K; EROKWU B; CHERNIACK NS;
Indirizzi:
CASE WESTERN RESERVE UNIV,SCH MED,DEPT MED,10900 EUCLID AVE CLEVELANDOH 44106
Titolo Testata:
Respiration physiology
fascicolo: 1-2, volume: 105, anno: 1996,
pagine: 35 - 45
SICI:
0034-5687(1996)105:1-2<35:CCEITC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL NERVOUS-SYSTEM; BRAIN-STEM; RAT; CHEMOSENSITIVITY; HYPERCAPNIA; NUCLEUS; HYPOXIA; MEDULLA; CHEMORECEPTORS; IDENTIFICATION;
Keywords:
C-FOS, CATECHOLAMINERGIC NEURONS; CHEMOSENSITIVITY, CENTRAL, CO2; CONTROL OF BREATHING, CENTRAL CHEMOSENSITIVITY; MAMMALS, RAT; NEURONS, CATECHOLAMINERGIC, C-FOS EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Haxhiu et al., "CO2-INDUCED C-FOS EXPRESSION IN THE CNS CATECHOLAMINERGIC NEURONS", Respiration physiology, 105(1-2), 1996, pp. 35-45

Abstract

In these studies we examined c-fos expression in catecholaminergic neurons following exposure of unanesthetized rats to hypercapnic stress. Breathing a gas mixture with elevated CO2 (15% CO2, 21% O-2 and 64% N-2, or 15% CO2 balance O-2) for 60 min, induced activation of the c-fos gene in widespread regions of the CNS, as indicated by the expression of Fos-like immunoreactive protein (Fos). Similar results were obtained in carotid body denervated animals. Colocalization studies of tyrosine hydroxylase (TH) and Fos protein revealed that in the brainstem, 73 to 85% of noradrenaline-containing cells expressed Fos immunoreactivity. Double-labeled neurons were found in the ventrolateral medullaryreticular formation (A1 noradrenaline cells), in the dorsal aspect ofmedulla oblongata (A2 noradrenaline cells), in the ventrolateral pens(A5 noradrenaline cells), and in the locus coeruleus (A6 noradrenaline cells). However, over 90% of TH-immunoreactive neurons in the mesencephalon and diencephalon (dopaminergic cells) did not express Fos-likeimmunoreactivity in response to CO2. These results indicate that the brainstem noradrenaline-containing neurons are part of the neuronal networks that react to hypercapnic exposure.

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Documento generato il 03/04/20 alle ore 08:49:03