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Titolo:
LESIONS OF THE LATERAL PARABRACHIAL NUCLEUS BLOCK THE AVERSIVE MOTIVATIONAL EFFECTS OF BOTH MORPHINE AND MORPHINE-WITHDRAWAL BUT SPARE MORPHINES DISCRIMINATIVE PROPERTIES
Autore:
NADER K; BECHARA A; VANDERKOOY D;
Indirizzi:
UNIV TORONTO,DEPT ANAT & CELL BIOL,NEUROBIOL RES GRP,100 COLL ST TORONTO ON M5S 1A8 CANADA
Titolo Testata:
Behavioral neuroscience
fascicolo: 6, volume: 110, anno: 1996,
pagine: 1496 - 1502
SICI:
0735-7044(1996)110:6<1496:LOTLPN>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
STIMULUS; NALOXONE; BRAIN; RATS; NEUROBIOLOGY; OPIOIDS; OPIATES; NAIVE; DRUGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
K. Nader et al., "LESIONS OF THE LATERAL PARABRACHIAL NUCLEUS BLOCK THE AVERSIVE MOTIVATIONAL EFFECTS OF BOTH MORPHINE AND MORPHINE-WITHDRAWAL BUT SPARE MORPHINES DISCRIMINATIVE PROPERTIES", Behavioral neuroscience, 110(6), 1996, pp. 1496-1502

Abstract

This study examined if the aversive properties of morphine, the aversive properties of morphine withdrawal, and the discriminative properties of morph inc are mediated by common neurobiological substrates. Lesions of the lateral parabrachial nucleus, which blocked the aversive properties of morphine in the conditioned taste aversion paradigm, alsoblocked the acquisition of conditioned place aversions to environments paired with the aversive properties of morphine withdrawal in morphine-dependent rats. When morphine and saline were used as cues in a discrimination task, however, both sham-operated and lesioned rats were able to solve the task.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:24:32