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Titolo:
REPEATED ISOLATION IN THE NEONATAL RAT PRODUCES ALTERATIONS IN BEHAVIOR AND VENTRAL STRIATAL DOPAMINE RELEASE IN THE JUVENILE AFTER AMPHETAMINE CHALLENGE
Autore:
KEHOE P; SHOEMAKER WJ; TRIANO L; HOFFMAN J; ARONS C;
Indirizzi:
TRINITY COLL,DEPT PSYCHOL HARTFORD CT 06106 UNIV CONNECTICUT,CTR HLTH,DEPT PSYCHIAT STORRS CT 06269
Titolo Testata:
Behavioral neuroscience
fascicolo: 6, volume: 110, anno: 1996,
pagine: 1435 - 1444
SICI:
0735-7044(1996)110:6<1435:RIITNR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG PUPS; MATERNAL SEPARATION; EXTRACELLULAR DOPAMINE; INVIVO MICRODIALYSIS; ISOLATION-DISTRESS; STRESS; SENSITIZATION; RESPONSIVENESS; EXPERIENCES; DEPRIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
P. Kehoe et al., "REPEATED ISOLATION IN THE NEONATAL RAT PRODUCES ALTERATIONS IN BEHAVIOR AND VENTRAL STRIATAL DOPAMINE RELEASE IN THE JUVENILE AFTER AMPHETAMINE CHALLENGE", Behavioral neuroscience, 110(6), 1996, pp. 1435-1444

Abstract

Rat pups were isolated from the mother and nest for I hr per day fromPostnatal Day (PN) 2 to 9. At PN 27, rats were tested for behavioral responsiveness to 2.0 or 7.5 mg/kg amphetamine. Only isolated rats receiving the 7.5 mg/kg dose displayed increased activity scores, compared with nonisolated and nonhandled controls. Their increased activity is attributed to a slower latency to enter into stereotypy. In a secondexperiment, similarly treated groups were challenged by the 7.5 mg/kgdose during a session in which a microdialysis probe implanted in theventral striatum was being perfused. The challenge drug elicited a much greater increase in dialysate dopamine in isolated vs. nonisolated groups. Results are discussed with regard to dissociation between sensitized and subsensitized responses.

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Documento generato il 27/01/20 alle ore 14:00:57