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Titolo:
BEHAVIORAL SENSITIZATION TO COCAINE, BUT NOT COCAINE-CONDITIONED BEHAVIOR, IS ASSOCIATED WITH INCREASED DOPAMINE OCCUPATION OF ITS RECEPTORS IN THE NUCLEUS-ACCUMBENS
Autore:
BURECHAILO L; MARTINIVERSON MT;
Indirizzi:
UNIV WESTERN AUSTRALIA,DEPT PSYCHOL PERTH WA 6907 AUSTRALIA UNIV ALBERTA,DEPT PSYCHOL EDMONTON AB CANADA UNIV ALBERTA,NEUROCHEM RES UNIT,DEPT PSYCHIAT EDMONTON AB CANADA
Titolo Testata:
Behavioral neuroscience
fascicolo: 6, volume: 110, anno: 1996,
pagine: 1388 - 1396
SICI:
0735-7044(1996)110:6<1388:BSTCBN>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED LOCOMOTOR-ACTIVITY; VENTRAL TEGMENTAL AREA; EXTRACELLULAR DOPAMINE; MESOLIMBIC DOPAMINE; INDUCED HYPERACTIVITY; TIME COURSE; RATS; MORPHINE; RELEASE; AMPHETAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
L. Burechailo e M.T. Martiniverson, "BEHAVIORAL SENSITIZATION TO COCAINE, BUT NOT COCAINE-CONDITIONED BEHAVIOR, IS ASSOCIATED WITH INCREASED DOPAMINE OCCUPATION OF ITS RECEPTORS IN THE NUCLEUS-ACCUMBENS", Behavioral neuroscience, 110(6), 1996, pp. 1388-1396

Abstract

Rats had repeated treatments with cocaine associated with a specific context (paired group). Evidence for classical conditioning of cocaine's motor-activity effects and context-specific behavioral sensitization to cocaine was obtained, relative to vehicle-treated (control) and pseudoconditioned (unpaired) groups. only the paired group exhibiting context-specific behavioral sensitization had more dopamine bound to both D-1-like and D-2-like receptors in the nucleus accumbens than did rats in the control group receiving cocaine on the test day. No effectson receptor occupation were found in rats showing a classical conditioned response to a context previously paired with cocaine. Thus, sensitization to cocaine, but not classical conditioning of cocaine's behavioral effects, was associated with greater dopaminergic neurotransmission selectively in the nucleus accumbens.

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Documento generato il 25/01/20 alle ore 09:28:05