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Titolo:
CHROMOSOMAL-ABNORMALITIES IN CUTANEOUS T-CELL LYMPHOMA AND IN ITS PREMALIGNANT CONDITIONS AS DETECTED BY G-BANDING AND INTERPHASE CYTOGENETIC METHODS
Autore:
KARENKO L; HYYTINEN E; SARNA S; RANKI A;
Indirizzi:
UNIV HELSINKI,CENT HOSP,DEPT DERMATOL & VENEREAL DIS,MEILAHDENTIE 2 HELSINKI 00250 FINLAND TAMPERE UNIV,INST MED TECHNOL,CANC GENET LAB FIN-33101 TAMPERE FINLAND TAMPERE UNIV,DEPT DERMATOL & VENEREAL DIS FIN-33101 TAMPERE FINLAND TAMPERE UNIV HOSP TAMPERE FINLAND UNIV HELSINKI,DEPT PUBL HLTH FIN-00014 HELSINKI FINLAND
Titolo Testata:
Journal of investigative dermatology
fascicolo: 1, volume: 108, anno: 1997,
pagine: 22 - 29
SICI:
0022-202X(1997)108:1<22:CICTLA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-SITU HYBRIDIZATION; NON-HODGKINS-LYMPHOMA; SEZARY-SYNDROME; MYCOSIS-FUNGOIDES; CLINICOPATHOLOGICAL SUBSETS; SKIN; ABERRATIONS; LYMPHOCYTES; DIAGNOSIS; DELETIONS;
Keywords:
MYCOSIS FUNGOIDES; PARAPSORIASIS; CHROMOSOME; IN SITU HYBRIDIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
L. Karenko et al., "CHROMOSOMAL-ABNORMALITIES IN CUTANEOUS T-CELL LYMPHOMA AND IN ITS PREMALIGNANT CONDITIONS AS DETECTED BY G-BANDING AND INTERPHASE CYTOGENETIC METHODS", Journal of investigative dermatology, 108(1), 1997, pp. 22-29

Abstract

The etiology of cutaneous T-cell lymphomas (CTCL) is unknown, We studied the pattern of chromosomal abnormalities with G-banding and interphase in sib hybridization methods in blood mononuclear cells in 17 patients representing the different phases of CTCL or the premalignant condition, parapsoriasis en plaque, and in 10 control persons. We used biotinylated centromere-specific probes with fluorescent detection (FISH) for chromosomes 1, 11, 8, and 17 and similar, enzymatically detectable, digoxigenin-labeled probes for chromosomes 1, 6, 12, 17, and 18. In G-banding, all patients showed numerical and structural chromosome aberrations, Numerical aberrations of chromosomes 6, 13, 15, and 17, marker chromosomes, and structural aberrations of chromosomes 3, 9, and13 were increased in mycosis fungoides (MF) compared with healthy controls, In four of five patients the detection of a chromosomal clone preceded relapse or progression of the disease. In FISH of interphase cells, the cells abnormal for chromosomes 8 or 11, and for all four chromosomes collectively, were increased in MF and in Sezary Syndrome (SS). FISH and G-banding methods agreed statistically significantly for the detection of monosomy, Also, digoxigenin-labeled probes hybridized to interphases or mitoses detected aberrations corresponding to those observed with G-banding, Thus, chromosomally abnormal cells can be found in the peripheral blood of both parapsoriasis en plaque and CTCL patients, They can be detected with interphase cytogenetical methods, which obviates the need for dividing cells, often difficult to accomplish in CTCL.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 08:40:57