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Titolo:
DRUG-METABOLISM AS A CONFOUNDING FACTOR IN PK PD POPULATION APPROACHES/
Autore:
BALANT LP; GEXFABRY M; BALANTGORGIA E;
Indirizzi:
UNIV HOSP GENEVA,CLIN RES UNIT GENEVA SWITZERLAND UNIV HOSP GENEVA,DEPT PSYCHIAT,THERAPEUT DRUG MONITORING UNIT GENEVA SWITZERLAND
Titolo Testata:
Therapie
fascicolo: 4, volume: 51, anno: 1996,
pagine: 390 - 398
SICI:
0040-5957(1996)51:4<390:DAACFI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; HALOPERIDOL HALOPERIDOL RATIOS; STATE PLASMA-CONCENTRATIONS; SEROTONIN UPTAKE INHIBITORS; REDUCED HALOPERIDOL; STEADY-STATE; SCHIZOPHRENIC-PATIENTS; CLINICAL-RESPONSE; NORFLUOXETINE ENANTIOMERS; STEREOSELECTIVE DISPOSITION;
Keywords:
METABOLISM; POPULATION APPROACHES; PHARMACOKINETICS/PHARMACODYNAMICS; PSYCHOTROPIC DRUGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
69
Recensione:
Indirizzi per estratti:
Citazione:
L.P. Balant et al., "DRUG-METABOLISM AS A CONFOUNDING FACTOR IN PK PD POPULATION APPROACHES/", Therapie, 51(4), 1996, pp. 390-398

Abstract

Pharmacokinetic/pharmacodynamic population approaches aim at establishing relationships between dose, drug concentration of active principles and clinical response, accounting for factors responsible for interindividuals variability. Additional difficulties in the presence of metabolites include the need to decide a priori which metabolites should be monitored according to their respective role in efficacy and/or toxicity, the need to select appropriate selective analytical methods, and the requirement for more complex pharmacokinetic and/or pharmacodynamic models. These points are discussed more extensively for psychotropic drugs, and in particular for the active metabolites of phenothiazines, for reduced haloperidol, for the desmethylated and hydroxylated metabolites of tricyclic antidepressants, and for the desmethyl metabolites of the serotonin-specific reuptake inhibitors Fluoxetine and citalopram.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 14:07:52