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Titolo:
POSSIBLE CYTOPROTECTIVE MECHANISM IN RATS OF D-002, AN ANTI-ULCEROGENIC PRODUCT ISOLATED FROM BEESWAX
Autore:
CARBAJAL D; MOLINA V; VALDES S; ARRUZAZABALA L; RODEIRO I; MAS R; MAGRANER J;
Indirizzi:
NATL CTR SCI RES,CTR NAT PROD,DEPT PHARMACOL,AVE 25 & 158,CUBANACAN PLAYA,POST BOX 6990 HAVANA CUBA
Titolo Testata:
Journal of Pharmacy and Pharmacology
fascicolo: 8, volume: 48, anno: 1996,
pagine: 858 - 860
SICI:
0022-3573(1996)48:8<858:PCMIRO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
INCREASED VASCULAR-PERMEABILITY; GASTRIC-MUCOSA; ETHANOL; DAMAGE; INJURY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
D. Carbajal et al., "POSSIBLE CYTOPROTECTIVE MECHANISM IN RATS OF D-002, AN ANTI-ULCEROGENIC PRODUCT ISOLATED FROM BEESWAX", Journal of Pharmacy and Pharmacology, 48(8), 1996, pp. 858-860

Abstract

D-002 is an anti-ulcerogenic product, isolated from beeswax, which consists of a well-defined mixture of higher primary aliphatic alcohols. It is highly effective against ethanol-induced ulcers. This study wasdesigned to determine if D-002 shows cytoprotective properties on gastric mucosa in ethanol-induced ulcers. The involvement of endogenous prostaglandins in the protective effect of D-002 was also investigated. When a subulcerogenic dose of indomethacin (10 mg kg(-1)) was injected simultaneously with oral administration of ethanol, oral pre-treatment with D-002 (5-100 mg kg(-1)) partially inhibited the gastric protection. D-002 (5 and 25 mg kg(-1)) administered to normal rats significantly increased the soluble mucus content and also prevented its reduction in rats with ethanol-induced ulcers. In addition, D-002 administered at 5 and 25 mg kg(-1) prevented the increase of vascular permeability induced by ethanol (60%) and reduced the concentration of thromboxane B-2 (TXB(2)) in gastric mucosa of rats with ethanol-induced ulcers. These results support the hypothesis that the anti-ulcerogenic properties of D-002 could be related to a cytoprotective mechanism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 17:35:22