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Titolo:
ON THE IN-VIVO MODULATION OF NEOSTRIATAL DOPAMINE RELEASE BY FLUOXETINE AND 5-HYDROXY-L-TRYPTOPHAN IN CONSCIOUS RATS
Autore:
LI XM; PERRY KW; FULLER RW;
Indirizzi:
ELI LILLY & CO,LILLY CORP CTR,LILLY RES LABS,BLDG 48,DROP CODE 0510 INDIANAPOLIS IN 46285
Titolo Testata:
Journal of Pharmacy and Pharmacology
fascicolo: 8, volume: 48, anno: 1996,
pagine: 825 - 828
SICI:
0022-3573(1996)48:8<825:OTIMON>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRACELLULAR SEROTONIN; UPTAKE INHIBITION; LILLY 110140; MICRODIALYSIS; FENFLURAMINE; INVIVO; BRAIN; 5-HYDROXYTRYPTAMINE; ANTIDEPRESSANTS; FACILITATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
X.M. Li et al., "ON THE IN-VIVO MODULATION OF NEOSTRIATAL DOPAMINE RELEASE BY FLUOXETINE AND 5-HYDROXY-L-TRYPTOPHAN IN CONSCIOUS RATS", Journal of Pharmacy and Pharmacology, 48(8), 1996, pp. 825-828

Abstract

To help determine the nature of serotonergic regulation of dopamine activity in the brain an in-vivo microdialysis study has been performedin conscious rats to investigate the modulation of dopamine release in the neostriatum by 5-hydroxytryptamine (5-HT). The 5-HT uptake inhibitor, fluoxetine, and the 5-HT precursor, 5-hydroxy-L-tryptophan (5-HTP), were used to produce an increase in extracellular 5-HT concentration. Systemic administration of fluoxetine (10 mg kg(-1), s.c.) produced a 2- to 3-fold increase in extracellular 5-HT concentration but did not change extracellular dopamine concentration in the neostriatum. Go-administration of fluoxetine and 5-HTP (40 mg kg(-1), s.c.; 60-90 minafter fluoxetine) caused a highly significant tenfold increase in extracellular 5-HT concentration in the neostriatum with a slight but non-significant decrease in extracellular dopamine concentration. Pergolide, a dopamine D-2 agonist, given systemically caused a dramatic decrease in extracellular dopamine concentration demonstrating the responsiveness of the neurons. These results demonstrate that high concentrations of extracellular 5-HT do not modulate dopamine release in the neostriatum. The possibility that different 5-HT receptor subtypes may mediate different regulation of dopamine release remains to be explored.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 07:32:24