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Titolo:
MULTILOCATIONAL HEPATOCYTE TRANSPLANTATION FOR TREATMENT OF CONGENITAL ASCORBIC-ACID DEFICIENCY RATS
Autore:
NAKAZAWA F; ONODERA K; KATO K; SAWA M; KINO Y; IMAI M; KASAI S; MITO M; MATSUSHITA T; FUNATSU K;
Indirizzi:
ASAHIKAWA MED COLL,DEPT SURG 2,4-5 NISHI KAGURA ASAHIKAWA HOKKAIDO 078 JAPAN KYUSHU UNIV,FAC ENGN,DEPT CHEM ENGN,HIGASHI KU FUKUOKA 812 JAPAN
Titolo Testata:
Cell transplantation
fascicolo: 5, volume: 5, anno: 1996, supplemento:, 1
pagine: 23 - 25
SICI:
0963-6897(1996)5:5<23:MHTFTO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPLEEN;
Keywords:
MULTILOCATIONAL HEPATOCYTE TRANSPLANTATION; POLYURETHANE FOAM (PUF); ASCORBIC ACID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
7
Recensione:
Indirizzi per estratti:
Citazione:
F. Nakazawa et al., "MULTILOCATIONAL HEPATOCYTE TRANSPLANTATION FOR TREATMENT OF CONGENITAL ASCORBIC-ACID DEFICIENCY RATS", Cell transplantation, 5(5), 1996, pp. 23-25

Abstract

We attempted multilocational hepatocyte transplantation (HCTx) including hepatocyte-bearing polyurethane foam (PUF) to treat congenitally ascorbic acid (AsA) biosynthetic enzyme-deficient (ODS-(od)/od) rats. Hepatocytes isolated from the liver of congenic rats were transplanted into the portal vein (Pv), spleen (Sp), omentum (Om), and mesentery (Ms). Hepatocyte-bearing PUF was transplanted into the Om and Ms. Experimental groups were divided into four groups (group I; Pv + Sp, group II; Pv + Sp + Om + Ms, group III; Pv + Sp + hepatocyte-bearing PUF, group TV; control). The average serum AsA level of the surviving rats in group II and III was significantly higher than that in group I 3 mo after HCTx. Histological examination showed small foci of surviving hepatocytes in the Om and Ms tissues and in the connective tissue in the PUF. ODS-(od)/od rats survived for a long time by multilocational HCTx.

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Documento generato il 29/11/20 alle ore 09:32:36