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Titolo:
HUMAN CHORIONIC-GONADOTROPIN INDUCES NITRIC-OXIDE SYNTHASE MESSENGER-RNA IN MOUSE PERITONEAL-MACROPHAGES
Autore:
KIM HM; MOON YH;
Indirizzi:
WONKWANG UNIV,COLL PHARM CHONJU 570749 SOUTH KOREA WONKWANG UNIV,SCH MED,DEPT CLIN PATHOL CHONJU 570749 SOUTH KOREA
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 2, volume: 229, anno: 1996,
pagine: 548 - 552
SICI:
0006-291X(1996)229:2<548:HCINSM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUTEINIZING-HORMONE RECEPTOR; CLONING; EXPRESSION; ENZYME; CDNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
H.M. Kim e Y.H. Moon, "HUMAN CHORIONIC-GONADOTROPIN INDUCES NITRIC-OXIDE SYNTHASE MESSENGER-RNA IN MOUSE PERITONEAL-MACROPHAGES", Biochemical and biophysical research communications, 229(2), 1996, pp. 548-552

Abstract

We examined the effects of human chorionic gonadotropin (hCG) on the production of nitric oxide (NO) by mouse peritoneal macrophages. hCG had no effect on NO synthesis by itself, whereas recombinant interferon-gamma (rIFN-gamma) alone had modest activity. When hCG was used in combination with rIFN-gamma, there was a marked cooperative induction ofNO synthesis in a dose-dependent manner. The optimal effect of hCG onNO synthesis was shown at 6 h after treatment with rIFN-gamma. This increase in NO synthesis was reflected as increased amount of inducibleNO synthase (iNOS) mRNA. N-G-monomethyl-L-arginine, and arginase inhibited rIFN-gamma-plus-hCG-induced NO production. On the basis of theseobservations, we conclude that hCG activates expression of iNOS mRNA in mouse peritoneal macrophages accompanied by NO accumulation via pathway dependent on L-arginine in the culture medium. (C) 1996 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 09:53:25