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Titolo:
VOMERONASAL ORGAN GROWTH AND DEVELOPMENT IN NORMAL AND CLEFT-LIP AND PALATE HUMAN FETUSES
Autore:
SMITH TD; SIEGEL MI; MOONEY MP; BURDI AR; TODHUNTER JS;
Indirizzi:
SLIPPERY ROCK UNIV,SCH PHYS THERAPY SLIPPERY ROCK PA 16057 UNIV PITTSBURGH,DEPT ANTHROPOL PITTSBURGH PA 15260 CLEFT PALATE CRANIOFACIAL CTR PITTSBURGH PA 00000 UNIV PITTSBURGH,DEPT ANAT & HISTOL PITTSBURGH PA 15260 UNIV PITTSBURGH,DEPT PLAST SURG PITTSBURGH PA 15260 UNIV PITTSBURGH,DEPT ANTHROPOL PITTSBURGH PA 15260 UNIV MICHIGAN,DEPT ANAT & CELL BIOL ANN ARBOR MI 48109 UNIV MICHIGAN,CTR HUMAN GROWTH & DEV ANN ARBOR MI 48109
Titolo Testata:
The Cleft palate-craniofacial journal
fascicolo: 5, volume: 33, anno: 1996,
pagine: 385 - 394
SICI:
1055-6656(1996)33:5<385:VOGADI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
3-DIMENSIONAL COMPUTER RECONSTRUCTION; HUMAN-FETAL SPECIMENS; STAGED HUMAN-EMBRYOS; JACOBSON ORGAN; CELLS; ULTRASTRUCTURE; VARIABILITY; SYSTEM;
Keywords:
ANTERIOR PARASEPTAL CARTILAGES; CLEFT LIP AND PALATE; FETAL GROWTH AND DEVELOPMENT; NASAL CAPSULE; VOMERONASAL ORGAN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
T.D. Smith et al., "VOMERONASAL ORGAN GROWTH AND DEVELOPMENT IN NORMAL AND CLEFT-LIP AND PALATE HUMAN FETUSES", The Cleft palate-craniofacial journal, 33(5), 1996, pp. 385-394

Abstract

As part of an ongoing investigation of normal and cleft lip and palate (CLP) fetal midfacial development, the vomeronasal organ (VNO) was examined in 35 human fetuses (26 normal and 9 CLP) ranging in age from 8 to 30 weeks postmenstrual age. All specimens were examined histologically, and a computer reconstruction technique was used to quantify lengths and volumes of right and left VNOs and anterior paraseptal cartilages (PCs). Growth curves were generated for these data and were compared between normal and cleft samples. VNOs and PCs were present in all normal fetuses, whereas VNOs were found in only 5 of 9 CLP specimensand PCs were found in 8 CLP specimens. The side of the palatal cleft in specimens with unilateral CLP was associated with PC dysmorphologies but appeared to have no influence on VNO presence or absence. Septaldysmorphologies were observed in most CLP specimens with absent or abnormal VNOs. VNO length increased in a linear fashion across ages, andVNO volume was seen to change in a logarithmic fashion. Individual CLP specimens did not differ significantly from the mean of the normal sample for VNO length or volume. PC length was seen to change in a sigmoidal fashion, and PC volume changes were best described by a logarithmic curve. In contrast to findings on the VNO, CLP specimens exhibitedsignificantly different growth rates (line slopes) for PC length and volume compared to the normal sample. Results on the normal sample suggested that the human fetal VNO exhibits volumetric increases between the 16th and 30th weeks of development, but this increase begins laterand proceeds more slowly than that of the PCs. Examination of the CLPsample suggested that the VNOs were of ''normal'' size for age, but may be vulnerable to septal dysmorphologies that result in altered location or disruption.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 20:59:12